Title |
Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis
|
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Published in |
Arthritis Research & Therapy, February 2012
|
DOI | 10.1186/ar3735 |
Pubmed ID | |
Authors |
Mitsuhiko Sato, Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Alexander Rodriguez Guerrero, Shuji Watanabe, Sally Roberts, Hisatoshi Baba |
Abstract |
Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support cell viability and differentiation and its retention and degradation in situ. The application of MSCs via a scaffold also requires a technically demanding surgical procedure. The aim of this study was to test the outcome of intra-articular transplantation of mesenchymal stem cells suspended in hyaluronic acid (HA) in the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis (OA). |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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