Title |
Androgen receptor signalling in Vascular Endothelial cells is dispensable for spermatogenesis and male fertility
|
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Published in |
BMC Research Notes, January 2012
|
DOI | 10.1186/1756-0500-5-16 |
Pubmed ID | |
Authors |
Laura O'Hara, Lee B Smith |
Abstract |
Androgen signalling is essential both for male development and function of the male reproductive system in adulthood. Within the adult testis, Germ cells (GC) do not express androgen receptor (AR) suggesting androgen-mediated promotion of spermatogenesis must act via AR-expressing somatic cell-types. Several recent studies have exploited the Cre/lox system of conditional gene-targeting to ablate AR function from key somatic cell-types in order to establish the cell-specific role of AR in promotion of male fertility. In this study, we have used a similar approach to specifically ablate AR-signalling from Vascular Endothelial (VE) cells, with a view to defining the significance of androgen signalling within this cell-type on spermatogenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 29% |
Student > Doctoral Student | 3 | 14% |
Student > Bachelor | 2 | 10% |
Researcher | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 2 | 10% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 19% |