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Herbal therapy for treating rheumatoid arthritis

Overview of attention for article published in Cochrane database of systematic reviews, January 2001
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Herbal therapy for treating rheumatoid arthritis
Published in
Cochrane database of systematic reviews, January 2001
DOI 10.1002/14651858.cd002948
Pubmed ID

Christine V Little, Tessa Parsons, Little, C, Parsons, T, Little, Christine V, Parsons, Tessa


The increasing popularity of the use of complementary and alternative interventions or treatments appears to be particularly evident amongst people with chronic disease. In the treatment of rheumatoid arthritis, one therapy that has been identified as having potential benefit, is herbal medicine (phytotherapy). To assess the effectiveness of herbal therapies in the treatment of rheumatoid arthritis. We developed a search strategy using terms to include all forms of arthritis combined with herbal medicine. We searched the following electronic databases from 1966 to 2000: MEDLINE, EMBASE, CISCOM, AMED, CINAHL, Cochrane Controlled Trials Register (CCTR), Cochrane Musculoskeletal specialized register, Dissertation Abstracts, BIDS ISI and the Cochrane Complementary Medicine Fields Specialized Register. This was supplemented by searching the reference lists from retrieved trials. All randomized trials of herbal interventions in rheumatoid arthritis, compared to placebo. Two reviewers independently read and selected each potential study according to the criteria published in an a priori protocol. Papers of any language were included. Data were extracted independently by the same two reviewers and an assessment of methodological quality was conducted. Eleven studies met the inclusion criteria. Seven of the studies compared gamma-linolenic acid (GLA) to placebo although three of these were not suitable for data pooling. The remaining studies considered four different herbal interventions and were assessed individually. All of the GLA studies found some improvement in clinical outcomes but methodology and study quality was variable, making it difficult to draw conclusive results. However, the better quality studies suggest potential relief of pain, morning stiffness and joint tenderness. With the exception of one intervention (Tripterygium wilfordii hook F), no serious side effects were reported. There appears to be some potential benefit for the use of GLA in rheumatoid arthritis although further studies are required to establish optimum dosage and duration of treatment. The single studies are inconclusive.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Other 7 21%
Student > Bachelor 5 15%
Student > Postgraduate 3 9%
Professor > Associate Professor 3 9%
Student > Master 3 9%
Other 8 24%
Unknown 5 15%
Readers by discipline Count As %
Medicine and Dentistry 14 41%
Biochemistry, Genetics and Molecular Biology 5 15%
Nursing and Health Professions 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Psychology 2 6%
Other 3 9%
Unknown 6 18%