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Japanese encephalitis virus tropism in experimentally infected pigs

Overview of attention for article published in Veterinary Research, January 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

twitter
4 tweeters

Citations

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48 Dimensions

Readers on

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71 Mendeley
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Title
Japanese encephalitis virus tropism in experimentally infected pigs
Published in
Veterinary Research, January 2016
DOI 10.1186/s13567-016-0319-z
Pubmed ID
Authors

Meret E. Ricklin, Obdulio Garcìa-Nicolàs, Daniel Brechbühl, Sylvie Python, Beatrice Zumkehr, Horst Posthaus, Anna Oevermann, Artur Summerfield

Abstract

Pigs are considered to be the main amplifying host for Japanese encephalitis virus (JEV), and their infection can correlate with human cases of disease. Despite their importance in the ecology of the virus as it relates to human cases of encephalitis, the pathogenesis of JEV in pigs remains obscure. In the present study, the localization and kinetics of virus replication were investigated in various tissues after experimental intravenous infection of pigs. The data demonstrate a rapid and broad spreading of the virus to the central nervous system (CNS) and various other organs. A particular tropism of JEV in pigs not only to the CNS but also for secondary lymphoid tissue, in particular the tonsils with the overall highest viral loads, was observed. In this organ, even 11 days post infection, the latest time point of the experiment, no apparent decrease in viral RNA loads and live virus was found despite the presence of a neutralizing antibody response. This was also well beyond the clinical and viremic phase. These results are of significance for the pathogenesis of JEV, and call for further experimental studies focusing on the cellular source and duration of virus replication in pigs.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 14%
Student > Master 10 14%
Other 8 11%
Student > Ph. D. Student 6 8%
Student > Bachelor 5 7%
Other 17 24%
Unknown 15 21%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 12 17%
Agricultural and Biological Sciences 10 14%
Biochemistry, Genetics and Molecular Biology 9 13%
Medicine and Dentistry 7 10%
Unspecified 3 4%
Other 14 20%
Unknown 16 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2016.
All research outputs
#3,491,750
of 8,380,241 outputs
Outputs from Veterinary Research
#238
of 595 outputs
Outputs of similar age
#108,450
of 288,735 outputs
Outputs of similar age from Veterinary Research
#9
of 25 outputs
Altmetric has tracked 8,380,241 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 595 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,735 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.