Title |
Specific immunotherapy generates CD8+ CD196+ T cells to suppress lung cancer growth in mice
|
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Published in |
Immunologic Research, February 2016
|
DOI | 10.1007/s12026-016-8793-y |
Pubmed ID | |
Authors |
Jian Zhang, Jing Liu, Huiguo Chen, Weibin Wu, Xiaojun Li, Yonghui Wu, Zhigang Wang, Kai Zhang, Yun Li, Yimin Weng, Hongying Liao, Lijia Gu |
Abstract |
That specific immunotherapy can inhibit cancer growth has been recognized; its efficiency is to be improved. This study aimed to inhibit lung cancer (LC) growth in a mouse model by using an LC-specific vaccination. In this study, a LC mouse model was created by adoptive transplantation with LC cells. The tumor-bearing mice were vaccinated with LC cell extracts plus adjuvant TNBS or adoptive transplantation with specific CD8(+) CD196(+) T cells. The results showed that the vaccination with LC extracts (LCE)/TNBS markedly inhibited the LC growth and induced CD8(+) CD196(+) T cells in LC tissue and the spleen. These CD8(+) CD196(+) T cells proliferated and produce high levels of perforin upon exposure to LCE and specifically induced LC cell apoptosis. Exposure to TNBS induced RAW264.7 cells to produce macrophage inflammatory protein-3α; the latter activated signal transducer and activator of transcription 3 and further induced perforin expression in the CD8(+) CD196(+) T cells. Adoptive transfer with specific CD8(+) CD196(+) T cells suppressed LC growth in mice. In conclusion, immunization with LC extracts and TNBS can induce LC-specific CD8(+) CD196(+) T cells in LC-bearing mice and inhibit LC growth. |
X Demographics
Geographical breakdown
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Russia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 27% |
Student > Bachelor | 3 | 27% |
Student > Doctoral Student | 1 | 9% |
Professor | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 0 | 0% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 45% |
Biochemistry, Genetics and Molecular Biology | 2 | 18% |
Neuroscience | 1 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Unknown | 2 | 18% |