Title |
Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution
|
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Published in |
International Journal of Nanomedicine, March 2016
|
DOI | 10.2147/ijn.s97000 |
Pubmed ID | |
Authors |
Dong Ryeol Lee, Ji Su Park, Il Hak Bae, Yan Lee, B Moon Kim |
Abstract |
Liquid crystal nanoparticles have been utilized as an efficient tool for drug delivery with enhanced bioavailability, drug stability, and targeted drug delivery. However, the high energy requirements and the high cost of the liquid crystal preparation have been obstacles to their widespread use in the pharmaceutical industry. In this study, we prepared liquid crystal nanoparticles using a phase-inversion temperature method, which is a uniquely low energy process. Particles prepared with the above method were estimated to be ~100 nm in size and exhibited a lamellar liquid crystal structure with orthorhombic lateral packing. Pharmacokinetic and tissue distribution studies of a hydrophobic peptide-based drug candidate formulated with the liquid crystal nanoparticles showed a five-fold enhancement of bioavailability, sustained release, and liver-specific drug delivery compared to a host-guest complex formulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 13% |
Student > Master | 8 | 12% |
Student > Bachelor | 8 | 12% |
Researcher | 6 | 9% |
Other | 4 | 6% |
Other | 9 | 13% |
Unknown | 25 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 20% |
Chemistry | 8 | 12% |
Medicine and Dentistry | 5 | 7% |
Agricultural and Biological Sciences | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Other | 9 | 13% |
Unknown | 25 | 36% |