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Local bacteria affect the efficacy of chemotherapeutic drugs

Overview of attention for article published in Scientific Reports, September 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

patent
1 patent

Citations

dimensions_citation
134 Dimensions

Readers on

mendeley
186 Mendeley
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Title
Local bacteria affect the efficacy of chemotherapeutic drugs
Published in
Scientific Reports, September 2015
DOI 10.1038/srep14554
Pubmed ID
Authors

Panos Lehouritis, Joanne Cummins, Michael Stanton, Carola T. Murphy, Florence O. McCarthy, Gregor Reid, Camilla Urbaniak, William L. Byrne, Mark Tangney

Abstract

In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in vivo for changes in the efficacy of cancer cell killing mediated by chemotherapeutic agents. Of 30 drugs examined in vitro, the efficacy of 10 was found to be significantly inhibited by certain bacteria, while the same bacteria improved the efficacy of six others. HPLC and mass spectrometry analyses of sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated modification of drug chemical structure. The chemoresistance or increased cytotoxicity observed in vitro with sample drugs (gemcitabine and CB1954) was replicated in in vivo murine subcutaneous tumour models. These findings suggest that bacterial presence in the body due to systemic or local infection may influence tumour responses or off-target toxicity during chemotherapy.

Mendeley readers

The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 2 1%
Germany 1 <1%
Unknown 181 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 19%
Student > Bachelor 29 16%
Researcher 28 15%
Student > Master 23 12%
Other 14 8%
Other 26 14%
Unknown 31 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 42 23%
Medicine and Dentistry 29 16%
Agricultural and Biological Sciences 26 14%
Immunology and Microbiology 20 11%
Chemistry 6 3%
Other 23 12%
Unknown 40 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2016.
All research outputs
#2,562,705
of 9,583,549 outputs
Outputs from Scientific Reports
#16,510
of 45,822 outputs
Outputs of similar age
#94,506
of 291,118 outputs
Outputs of similar age from Scientific Reports
#1,197
of 3,119 outputs
Altmetric has tracked 9,583,549 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 45,822 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,118 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 3,119 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.