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Increased NOS2 predicts poor survival in estrogen receptor–negative breast cancer patients

Overview of attention for article published in Journal of Clinical Investigation, November 2010
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  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

patent
1 patent

Citations

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158 Dimensions

Readers on

mendeley
73 Mendeley
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Title
Increased NOS2 predicts poor survival in estrogen receptor–negative breast cancer patients
Published in
Journal of Clinical Investigation, November 2010
DOI 10.1172/jci42059
Pubmed ID
Authors

Sharon A. Glynn, Brenda J. Boersma, Tiffany H. Dorsey, Ming Yi, Harris G. Yfantis, Lisa A. Ridnour, Damali N. Martin, Christopher H. Switzer, Robert S. Hudson, David A. Wink, Dong H. Lee, Robert M. Stephens, Stefan Ambs

Abstract

Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation and increased nitric oxide (NO) production affect the redox state of cells and can induce protein, lipid, and DNA modifications. To investigate whether NOS2 levels influence survival of breast cancer patients, we examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors. In multivariable survival analysis, increased NOS2 predicted inferior survival in women with estrogen receptor α-negative (ER-negative) tumors. Microdissected tumor epithelium from ER-negative tumors with high NOS2 had increased IL-8 and a gene expression signature characteristic of basal-like breast cancer with poor prognosis. In cell culture, NO only induced selected signature genes in ER-negative breast cancer cells. ER transgene expression in ER-negative cells inhibited NO-induced upregulation of the stem cell marker CD44 and other proteins encoded by signature genes, but not of IL-8. Exposure to NO also enhanced cell motility and invasion of ER-negative cells. Last, pathway analysis linked the tumor NOS2 gene signature to c-Myc activation. Thus, NOS2 is associated with a basal-like transcription pattern and poor survival of ER-negative patients.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
France 1 1%
United Kingdom 1 1%
Spain 1 1%
United States 1 1%
Unknown 68 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 19%
Researcher 14 19%
Student > Master 10 14%
Student > Bachelor 9 12%
Professor > Associate Professor 5 7%
Other 11 15%
Unknown 10 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 33%
Biochemistry, Genetics and Molecular Biology 16 22%
Medicine and Dentistry 10 14%
Immunology and Microbiology 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 4 5%
Unknown 13 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2019.
All research outputs
#5,608,892
of 17,362,547 outputs
Outputs from Journal of Clinical Investigation
#8,013
of 14,906 outputs
Outputs of similar age
#92,067
of 271,408 outputs
Outputs of similar age from Journal of Clinical Investigation
#77
of 119 outputs
Altmetric has tracked 17,362,547 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.