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Zika Virus Infection in Pregnant Women in Rio de Janeiro

Overview of attention for article published in New England Journal of Medicine, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 24,761)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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Readers on

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153 Mendeley
Title
Zika Virus Infection in Pregnant Women in Rio de Janeiro
Published in
New England Journal of Medicine, December 2016
DOI 10.1056/nejmoa1602412
Pubmed ID
Authors

Patrícia Brasil, José P. Pereira, M. Elisabeth Moreira, Rita M. Ribeiro Nogueira, Luana Damasceno, Mayumi Wakimoto, Renata S. Rabello, Stephanie G. Valderramos, Umme-Aiman Halai, Tania S. Salles, Andrea A. Zin, Dafne Horovitz, Pedro Daltro, Marcia Boechat, Claudia Raja Gabaglia, Patrícia Carvalho de Sequeira, José H. Pilotto, Raquel Medialdea-Carrera, Denise Cotrim da Cunha, Liege M. Abreu de Carvalho, Marcos Pone, André Machado Siqueira, Guilherme A. Calvet, Ana E. Rodrigues Baião, Elizabeth S. Neves, Paulo R. Nassar de Carvalho, Renata H. Hasue, Peter B. Marschik, Christa Einspieler, Carla Janzen, James D. Cherry, Ana M. Bispo de Filippis, Karin Nielsen-Saines

Abstract

Background Zika virus (ZIKV) has been linked to neonatal microcephaly. To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses. Methods We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase-polymerase-chain-reaction assays. We followed the women prospectively and collected clinical and ultrasonographic data. Results A total of 88 women were enrolled from September 2015 through February 2016; of these 88 women, 72 (82%) tested positive for ZIKV in blood, urine, or both. The timing of acute ZIKV infection ranged from 5 to 38 weeks of gestation. Predominant clinical features included pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 28% had fever (short-term and low-grade). Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). Fetal ultrasonography was performed in 42 ZIKV-positive women (58%) and in all ZIKV-negative women. Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses). To date, 8 of the 42 women in whom fetal ultrasonography was performed have delivered their babies, and the ultrasonographic findings have been confirmed. Conclusions Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 153 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 28 18%
Researcher 27 18%
Unspecified 26 17%
Student > Master 18 12%
Student > Ph. D. Student 15 10%
Other 39 25%
Readers by discipline Count As %
Medicine and Dentistry 53 35%
Unspecified 37 24%
Immunology and Microbiology 15 10%
Agricultural and Biological Sciences 12 8%
Biochemistry, Genetics and Molecular Biology 11 7%
Other 25 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2135. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2018.
All research outputs
#531
of 12,518,379 outputs
Outputs from New England Journal of Medicine
#31
of 24,761 outputs
Outputs of similar age
#20
of 268,860 outputs
Outputs of similar age from New England Journal of Medicine
#3
of 356 outputs
Altmetric has tracked 12,518,379 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 24,761 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,860 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 356 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.