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Zika Virus Infection in Pregnant Women in Rio de Janeiro

Overview of attention for article published in New England Journal of Medicine, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1334 Dimensions

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1401 Mendeley
Title
Zika Virus Infection in Pregnant Women in Rio de Janeiro
Published in
New England Journal of Medicine, December 2016
DOI 10.1056/nejmoa1602412
Pubmed ID
Authors

Patrícia Brasil, José P. Pereira, M. Elisabeth Moreira, Rita M. Ribeiro Nogueira, Luana Damasceno, Mayumi Wakimoto, Renata S. Rabello, Stephanie G. Valderramos, Umme-Aiman Halai, Tania S. Salles, Andrea A. Zin, Dafne Horovitz, Pedro Daltro, Marcia Boechat, Claudia Raja Gabaglia, Patrícia Carvalho de Sequeira, José H. Pilotto, Raquel Medialdea-Carrera, Denise Cotrim da Cunha, Liege M. Abreu de Carvalho, Marcos Pone, André Machado Siqueira, Guilherme A. Calvet, Ana E. Rodrigues Baião, Elizabeth S. Neves, Paulo R. Nassar de Carvalho, Renata H. Hasue, Peter B. Marschik, Christa Einspieler, Carla Janzen, James D. Cherry, Ana M. Bispo de Filippis, Karin Nielsen-Saines

Abstract

Background Zika virus (ZIKV) has been linked to neonatal microcephaly. To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses. Methods We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase-polymerase-chain-reaction assays. We followed the women prospectively and collected clinical and ultrasonographic data. Results A total of 88 women were enrolled from September 2015 through February 2016; of these 88 women, 72 (82%) tested positive for ZIKV in blood, urine, or both. The timing of acute ZIKV infection ranged from 5 to 38 weeks of gestation. Predominant clinical features included pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 28% had fever (short-term and low-grade). Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). Fetal ultrasonography was performed in 42 ZIKV-positive women (58%) and in all ZIKV-negative women. Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses). To date, 8 of the 42 women in whom fetal ultrasonography was performed have delivered their babies, and the ultrasonographic findings have been confirmed. Conclusions Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury.

Twitter Demographics

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Mendeley readers

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Geographical breakdown

Country Count As %
Brazil 23 2%
United States 12 <1%
United Kingdom 5 <1%
Colombia 2 <1%
Switzerland 2 <1%
Spain 2 <1%
Netherlands 1 <1%
Tanzania, United Republic of 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 1351 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 256 18%
Student > Master 236 17%
Researcher 181 13%
Student > Ph. D. Student 160 11%
Student > Postgraduate 94 7%
Other 311 22%
Unknown 163 12%
Readers by discipline Count As %
Medicine and Dentistry 464 33%
Agricultural and Biological Sciences 172 12%
Biochemistry, Genetics and Molecular Biology 133 9%
Immunology and Microbiology 105 7%
Nursing and Health Professions 78 6%
Other 224 16%
Unknown 225 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2119. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2020.
All research outputs
#2,149
of 18,017,546 outputs
Outputs from New England Journal of Medicine
#132
of 28,559 outputs
Outputs of similar age
#30
of 272,931 outputs
Outputs of similar age from New England Journal of Medicine
#2
of 342 outputs
Altmetric has tracked 18,017,546 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 28,559 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 95.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 342 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.