Title |
Gene expression profile changes in Eisenia fetida chronically exposed to PFOA
|
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Published in |
Ecotoxicology, March 2016
|
DOI | 10.1007/s10646-016-1634-x |
Pubmed ID | |
Authors |
Srinithi Mayilswami, Kannan Krishnan, Mallavarapu Megharaj, Ravi Naidu |
Abstract |
Eisenia fetida is a terrestrial organism, which can be used to diagnose sub-lethal concentrations of PFOA by using molecular biomarkers. In order to identify potential molecular biomarkers, we have exposed E. fetida to 10 mg/kg of PFOA in soil for 8 months. The mRNA isolation, sequencing, transcriptome assembly followed by differential gene expression studies have revealed that genes that are involved in apoptotic process, reproduction, calcium signalling, neuronal development and lipid metabolism are predominantly affected. Highly specific genes that are altered by PFOA can be further validated and used as biomarker to detect sub-lethal concentrations of PFOA in the soil. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 22% |
Researcher | 3 | 13% |
Professor > Associate Professor | 3 | 13% |
Student > Doctoral Student | 2 | 9% |
Student > Master | 1 | 4% |
Other | 2 | 9% |
Unknown | 7 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 22% |
Environmental Science | 2 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Computer Science | 2 | 9% |
Medicine and Dentistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 43% |