The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation
|
|---|---|
| Published in |
Cerebral Cortex, March 2016
|
| DOI | 10.1093/cercor/bhw035 |
| Pubmed ID | |
| Authors |
Adam J. Kundishora, Abhijeet Gummadavelli, Chanthia Ma, Mengran Liu, Cian McCafferty, Nicholas D. Schiff, Jon T. Willie, Robert E. Gross, Jason Gerrard, Hal Blumenfeld |
| Abstract |
Impaired consciousness occurs suddenly and unpredictably in people with epilepsy, markedly worsening quality of life and increasing risk of mortality. Focal seizures with impaired consciousness are the most common form of epilepsy and are refractory to all current medical and surgical therapies in about one-sixth of cases. Restoring consciousness during and following seizures would be potentially transformative for these individuals. Here, we investigate deep brain stimulation to improve level of conscious arousal in a rat model of focal limbic seizures. We found that dual-site stimulation of the central lateral nucleus of the intralaminar thalamus (CL) and the pontine nucleus oralis (PnO) bilaterally during focal limbic seizures restored normal-appearing cortical electrophysiology and markedly improved behavioral arousal. In contrast, single-site bilateral stimulation of CL or PnO alone was insufficient to achieve the same result. These findings support the "network inhibition hypothesis" that focal limbic seizures impair consciousness through widespread inhibition of subcortical arousal. Driving subcortical arousal function would be a novel therapeutic approach to some forms of refractory epilepsy and may be compatible with devices already in use for responsive neurostimulation. Multisite deep brain stimulation of subcortical arousal structures may benefit not only patients with epilepsy but also those with other disorders of consciousness. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| France | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 107 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 17% |
| Researcher | 19 | 17% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 8 | 7% |
| Student > Postgraduate | 8 | 7% |
| Other | 26 | 24% |
| Unknown | 21 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 35 | 32% |
| Medicine and Dentistry | 20 | 18% |
| Agricultural and Biological Sciences | 11 | 10% |
| Psychology | 9 | 8% |
| Engineering | 6 | 5% |
| Other | 6 | 5% |
| Unknown | 23 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2022.
All research outputs
#8,621,657
of 25,732,188 outputs
Outputs from Cerebral Cortex
#2,593
of 5,226 outputs
Outputs of similar age
#112,540
of 313,712 outputs
Outputs of similar age from Cerebral Cortex
#45
of 83 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 5,226 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,712 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.