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The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

Overview of attention for article published in European Review of Aging and Physical Activity, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#34 of 166)
  • High Attention Score compared to outputs of the same age (85th percentile)

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1 blog
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1 Facebook page

Citations

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28 Dimensions

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100 Mendeley
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Title
The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function
Published in
European Review of Aging and Physical Activity, March 2016
DOI 10.1186/s11556-016-0163-1
Pubmed ID
Authors

Hans Drenth, Sytse Zuidema, Steven Bunt, Ivan Bautmans, Cees van der Schans, Hans Hobbelen

Abstract

Diminishing motor function is commonly observed in the elderly population and is associated with a wide range of adverse health consequences. Advanced Glycation End products (AGE's) may contribute to age-related decline in the function of cells and tissues in normal ageing. Although the negative effect of AGE's on the biomechanical properties of musculoskeletal tissues and the central nervous system have been previously described, the evidence regarding the effect on motor function is fragmented, and a systematic review on this topic is lacking. Therefore, a systematic review was conducted from a total of eight studies describing AGE's related to physical functioning, physical performance, and musculoskeletal outcome which reveals a positive association between high AGE's levels and declined walking abilities, inferior ADL, decreased muscle properties (strength, power and mass) and increased physical frailty. Elevated AGE's levels might be an indication to initiate (early) treatment such as dietary advice, muscle strengthening exercises, and functional training to maintain physical functions. Further longitudinal observational and controlled trial studies are necessary to investigate a causal relationship, and to what extent, high AGE's levels are a contributing risk factor and potential biomarker for a decline in motor function as a component of the ageing process.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 100 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 16%
Student > Bachelor 15 15%
Student > Ph. D. Student 9 9%
Researcher 7 7%
Student > Doctoral Student 7 7%
Other 11 11%
Unknown 35 35%
Readers by discipline Count As %
Medicine and Dentistry 16 16%
Nursing and Health Professions 15 15%
Agricultural and Biological Sciences 9 9%
Sports and Recreations 8 8%
Biochemistry, Genetics and Molecular Biology 6 6%
Other 11 11%
Unknown 35 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2017.
All research outputs
#2,774,436
of 23,911,072 outputs
Outputs from European Review of Aging and Physical Activity
#34
of 166 outputs
Outputs of similar age
#43,683
of 302,527 outputs
Outputs of similar age from European Review of Aging and Physical Activity
#2
of 2 outputs
Altmetric has tracked 23,911,072 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 166 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,527 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.