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Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

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Title
Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats
Published in
Brazilian Oral Research, January 2016
DOI 10.1590/1807-3107bor-2016.vol30.0168
Pubmed ID
Authors

DE REZENDE BARBOSA, Gabriella Lopes, PIMENTA, Luiz André, ALMEIDA, Solange Maria de, DE REZENDE BARBOSA, Gabriella Lopes, PIMENTA, Luiz André, ALMEIDA, Solange Maria de

Abstract

The purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a microcomputed tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey's post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05). The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues.

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Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 20%
Student > Doctoral Student 2 13%
Other 2 13%
Student > Ph. D. Student 2 13%
Researcher 2 13%
Other 2 13%
Unknown 2 13%
Readers by discipline Count As %
Medicine and Dentistry 5 33%
Biochemistry, Genetics and Molecular Biology 2 13%
Agricultural and Biological Sciences 2 13%
Nursing and Health Professions 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 1 7%
Unknown 3 20%