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The Prevalence and Cost of Unapproved Uses of Top-Selling Orphan Drugs

Overview of attention for article published in PLOS ONE, February 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
policy
3 policy sources
twitter
6 X users
wikipedia
5 Wikipedia pages

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
85 Mendeley
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Title
The Prevalence and Cost of Unapproved Uses of Top-Selling Orphan Drugs
Published in
PLOS ONE, February 2012
DOI 10.1371/journal.pone.0031894
Pubmed ID
Authors

Aaron S. Kesselheim, Jessica A. Myers, Daniel H. Solomon, Wolfgang C. Winkelmayer, Raisa Levin, Jerry Avorn

Abstract

The Orphan Drug Act encourages drug development for rare conditions. However, some orphan drugs become top sellers for unclear reasons. We sought to evaluate the extent and cost of approved and unapproved uses of orphan drugs with the highest unit sales.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Brazil 1 1%
Netherlands 1 1%
India 1 1%
Luxembourg 1 1%
Unknown 79 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 19%
Student > Master 12 14%
Student > Ph. D. Student 10 12%
Other 10 12%
Student > Postgraduate 8 9%
Other 17 20%
Unknown 12 14%
Readers by discipline Count As %
Medicine and Dentistry 27 32%
Pharmacology, Toxicology and Pharmaceutical Science 12 14%
Agricultural and Biological Sciences 5 6%
Immunology and Microbiology 4 5%
Social Sciences 4 5%
Other 16 19%
Unknown 17 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2022.
All research outputs
#1,216,014
of 24,754,968 outputs
Outputs from PLOS ONE
#15,584
of 214,251 outputs
Outputs of similar age
#6,128
of 160,601 outputs
Outputs of similar age from PLOS ONE
#212
of 3,525 outputs
Altmetric has tracked 24,754,968 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 214,251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 3,525 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.