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Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948)

Overview of attention for article published in PLOS ONE, February 2012
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Title
Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948)
Published in
PLOS ONE, February 2012
DOI 10.1371/journal.pone.0026331
Pubmed ID
Authors

Chandrajit P. Raut, Yves Boucher, Dan G. Duda, Jeffrey A. Morgan, Richard Quek, Marek Ancukiewicz, Johanna Lahdenranta, J. Paul Eder, George D. Demetri, Rakesh K. Jain

Abstract

Sorafenib is a multi-targeted tyrosine kinase inhibitor with therapeutic efficacy in several malignancies. Sorafenib may exert its anti-neoplastic effect in part by altering vascular permeability and reducing intra-tumoral interstitial hypertension. As correlative science with a phase II study in patients with advanced soft-tissue sarcomas (STS), we evaluated the impact of this agent on intra-tumor interstitial fluid pressure (IFP), serum circulating biomarkers, and vascular density.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Student > Ph. D. Student 8 16%
Student > Bachelor 5 10%
Student > Master 4 8%
Other 4 8%
Other 8 16%
Unknown 12 24%
Readers by discipline Count As %
Medicine and Dentistry 15 29%
Engineering 6 12%
Agricultural and Biological Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 4 8%
Unknown 15 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2012.
All research outputs
#20,155,513
of 22,663,150 outputs
Outputs from PLOS ONE
#172,662
of 193,502 outputs
Outputs of similar age
#223,979
of 247,592 outputs
Outputs of similar age from PLOS ONE
#3,114
of 3,420 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,502 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,592 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,420 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.