Title |
Cost–benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke
|
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Published in |
European Journal of Epidemiology, March 2016
|
DOI | 10.1007/s10654-016-0122-1 |
Pubmed ID | |
Authors |
Nicholas J. Wald, Johannes Michiel Luteijn, Joan K. Morris, David Taylor, Peter Oppenheimer |
Abstract |
The primary prevention of cardiovascular disease is a public health priority. To assess the costs and benefits of a Polypill Prevention Programme using a daily 4-component polypill from age 50 in the UK, we determined the life years gained without a first myocardial infarction (MI) or stroke, together with the total service cost (or saving) and the net cost (or saving) per year of life gained without a first MI or stroke. This was estimated on the basis of a 50 % uptake and a previously published 83 % treatment adherence. The total years of life gained without a first MI or stroke in a mature programme is 990,000 each year in the UK. If the cost of the Polypill Prevention Programme were £1 per person per day, the total cost would be £4.76 bn and, given the savings (at 2014 prices) of £2.65 bn arising from the disease prevented, there would be a net cost of £2.11 bn representing a net cost per year of life gained without a first MI or stroke of £2120. The results are robust to sensitivity analyses. A national Polypill Prevention Programme would have a substantial effect in preventing MIs and strokes and be cost-effective. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Unknown | 72 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 18% |
Student > Master | 10 | 14% |
Student > Bachelor | 9 | 12% |
Student > Doctoral Student | 7 | 10% |
Professor | 5 | 7% |
Other | 14 | 19% |
Unknown | 15 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 27 | 37% |
Nursing and Health Professions | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Agricultural and Biological Sciences | 4 | 5% |
Other | 6 | 8% |
Unknown | 19 | 26% |