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Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior

Overview of attention for article published in Biological Research, March 2016
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

Mentioned by

twitter
8 tweeters

Citations

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17 Dimensions

Readers on

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87 Mendeley
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1 CiteULike
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Title
Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior
Published in
Biological Research, March 2016
DOI 10.1186/s40659-016-0076-5
Pubmed ID
Authors

Ignacio Negrón-Oyarzo, Ariel Lara-Vásquez, Ismael Palacios-García, Pablo Fuentealba, Francisco Aboitiz

Abstract

Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive function that is mainly dependent on the prefrontal cortex. This behavioral deficit, together with cellular and neurophysiological alterations in the prefrontal cortex, as well as reduced density of GABAergic cells and aberrant oscillatory activity, all indicate structural and functional deficits of the prefrontal cortex in schizophrenia. Among the several risk factors for the development of schizophrenia, stress during the prenatal period has been identified as crucial. Thus, it is proposed that prenatal stress induces neurodevelopmental alterations in the prefrontal cortex that are expressed as cognitive impairment observed in schizophrenia. However, the precise mechanisms that link prenatal stress with the impairment of prefrontal cortex function is largely unknown. Reelin is an extracellular matrix protein involved in the development of cortical neural connectivity at embryonic stages, and in synaptic plasticity at postnatal stages. Interestingly, down-regulation of reelin expression has been associated with epigenetic changes in the reelin gene of the prefrontal cortex of schizophrenic patients. We recently showed that, similar to schizophrenic patients, prenatal stress induces down-expression of reelin associated with the methylation of its promoter in the rodent prefrontal cortex. These alterations were paralleled with altered prefrontal cortex functional connectivity and impairment in prefrontal cortex-dependent behavioral tasks. Therefore, considering molecular, cellular, physiological and behavioral evidence, we propose a unifying framework that links prenatal stress and prefrontal malfunction through epigenetic alterations of the reelin gene.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 86 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 22%
Student > Ph. D. Student 18 21%
Student > Master 13 15%
Student > Postgraduate 7 8%
Researcher 6 7%
Other 11 13%
Unknown 13 15%
Readers by discipline Count As %
Neuroscience 21 24%
Agricultural and Biological Sciences 14 16%
Medicine and Dentistry 13 15%
Biochemistry, Genetics and Molecular Biology 8 9%
Psychology 6 7%
Other 8 9%
Unknown 17 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2016.
All research outputs
#7,173,001
of 14,167,968 outputs
Outputs from Biological Research
#79
of 381 outputs
Outputs of similar age
#96,963
of 266,601 outputs
Outputs of similar age from Biological Research
#1
of 1 outputs
Altmetric has tracked 14,167,968 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 381 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them