Title |
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
|
---|---|
Published in |
Reproductive Biology and Endocrinology, February 2012
|
DOI | 10.1186/1477-7827-10-14 |
Pubmed ID | |
Authors |
Yoshihiro Morita, Osamu Wada-Hiraike, Tetsu Yano, Akira Shirane, Mana Hirano, Haruko Hiraike, Satoshi Koyama, Hajime Oishi, Osamu Yoshino, Yuichiro Miyamoto, Kenbun Sone, Katsutoshi Oda, Shunsuke Nakagawa, Kazuyoshi Tsutsui, Yuji Taketani |
Abstract |
Resveratrol is a natural polyphenolic compound known for its beneficial effects on energy homeostasis, and it also has multiple properties, including anti-oxidant, anti-inflammatory, and anti-tumor activities. Recently, silent information regulator genes (Sirtuins) have been identified as targets of resveratrol. Sirtuin 1 (SIRT1), originally found as an NAD+-dependent histone deacetylase, is a principal modulator of pathways downstream of calorie restriction, and the activation of SIRT1 ameliorates glucose homeostasis and insulin sensitivity. To date, the presence and physiological role of SIRT1 in the ovary are not known. Here we found that SIRT1 was localized in granulosa cells of the human ovary. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 50% |
Trinidad and Tobago | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Portugal | 1 | 1% |
France | 1 | 1% |
Belarus | 1 | 1% |
Unknown | 88 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 17% |
Student > Ph. D. Student | 13 | 14% |
Student > Master | 9 | 10% |
Student > Bachelor | 9 | 10% |
Professor > Associate Professor | 8 | 9% |
Other | 21 | 23% |
Unknown | 17 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 25% |
Biochemistry, Genetics and Molecular Biology | 19 | 20% |
Medicine and Dentistry | 14 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Engineering | 2 | 2% |
Other | 9 | 10% |
Unknown | 23 | 25% |