Title |
Computerized Cognitive Training Restores Neural Activity within the Reality Monitoring Network in Schizophrenia
|
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Published in |
Neuron, February 2012
|
DOI | 10.1016/j.neuron.2011.12.024 |
Pubmed ID | |
Authors |
Karuna Subramaniam, Tracy L. Luks, Melissa Fisher, Gregory V. Simpson, Srikantan Nagarajan, Sophia Vinogradov |
Abstract |
Schizophrenia patients suffer from severe cognitive deficits, such as impaired reality monitoring. Reality monitoring is the ability to distinguish the source of internal experiences from outside reality. During reality monitoring tasks, schizophrenia patients make errors identifying "I made it up" items, and even during accurate performance, they show abnormally low activation of the medial prefrontal cortex (mPFC), a region that supports self-referential cognition. We administered 80 hr of computerized training of cognitive processes to schizophrenia patients and found improvement in reality monitoring that correlated with increased mPFC activity. In contrast, patients in a computer games control condition did not show any behavioral or neural improvements. Notably, recovery in mPFC activity after training was associated with improved social functioning 6 months later. These findings demonstrate that a serious behavioral deficit in schizophrenia, and its underlying neural dysfunction, can be improved by well-designed computerized cognitive training, resulting in better quality of life. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 28% |
Canada | 4 | 9% |
Spain | 3 | 7% |
United Kingdom | 2 | 5% |
Ireland | 2 | 5% |
Bulgaria | 1 | 2% |
Switzerland | 1 | 2% |
Comoros | 1 | 2% |
Sweden | 1 | 2% |
Other | 3 | 7% |
Unknown | 13 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 33 | 77% |
Scientists | 7 | 16% |
Science communicators (journalists, bloggers, editors) | 2 | 5% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 3% |
Switzerland | 2 | <1% |
Germany | 2 | <1% |
France | 1 | <1% |
Australia | 1 | <1% |
Finland | 1 | <1% |
Czechia | 1 | <1% |
Italy | 1 | <1% |
Canada | 1 | <1% |
Other | 3 | <1% |
Unknown | 402 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 75 | 18% |
Researcher | 75 | 18% |
Student > Master | 55 | 13% |
Student > Bachelor | 42 | 10% |
Student > Doctoral Student | 31 | 7% |
Other | 75 | 18% |
Unknown | 73 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 163 | 38% |
Medicine and Dentistry | 49 | 12% |
Neuroscience | 46 | 11% |
Agricultural and Biological Sciences | 36 | 8% |
Nursing and Health Professions | 8 | 2% |
Other | 27 | 6% |
Unknown | 97 | 23% |