Title |
Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians
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Published in |
Journal of Zhejiang University - Science B, May 2015
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DOI | 10.1631/jzus.b1400241 |
Pubmed ID | |
Authors |
Po Hu, Ming-yuan Huang, Xin-yang Hu, Xiao-jie Xie, Mei-xiang Xiang, Xian-bao Liu, Jian-an Wang |
Abstract |
A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T polymorphism and ACS. We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64-0.83), dominant model (OR 0.71; 95% CI 0.62-0.82), and homozygote comparison (OR 0.57; 95% CI 0.35-0.92). However, in the overall population and especially with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger's linear regression test. Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 2 | 14% |
Researcher | 2 | 14% |
Student > Postgraduate | 2 | 14% |
Student > Master | 2 | 14% |
Other | 1 | 7% |
Other | 3 | 21% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 43% |
Agricultural and Biological Sciences | 3 | 21% |
Environmental Science | 1 | 7% |
Engineering | 1 | 7% |
Unknown | 3 | 21% |