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Physicochemical, Morphological and Cellular Uptake Properties of Lutein Nanodispersions Prepared by Using Surfactants with Different Stabilizing Mechanisms

Overview of attention for article published in Food & Function, March 2016
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Title
Physicochemical, Morphological and Cellular Uptake Properties of Lutein Nanodispersions Prepared by Using Surfactants with Different Stabilizing Mechanisms
Published in
Food & Function, March 2016
DOI 10.1039/c5fo01621e
Pubmed ID
Authors

Tai Boon Tan, C.-W. Chu, Yussof Nor Shariffa, Faridah Abas, Hamed Mirhosseini, Yoke Kqueen Cheah, Nehdi A Imed, Chin Ping Tan, Wern Cui Chu, Nor Shariffa Yussof, Imededdine Arbi Nehdi

Abstract

In this study, we prepared a series of lutein nanodispersions via the solvent displacement method, by using surfactants with different stabilizing mechanisms. The surfactants used include Tween 80 (steric stabilization), sodium dodecyl sulfate (SDS; electrostatic stabilization), sodium caseinate (electrosteric stabilization) and SDS-Tween 80 (electrostatic-steric stabilization). We then characterized the resulting lutein nanodispersions in terms of their particle size, particle size distribution, zeta potential, lutein content, flow behavior, apparent viscosity, transmittance, color, morphological properties and their effects on cell viability and cellular uptake. The type of surfactant used significantly (p < 0.05) affected the physical properties of the nanodispersions, but the chemical properties (lutein content) remained unaffected. Transmission electron microscopy (TEM) images obtained from this study demonstrated that the solvent displacement method was capable of producing lutein nanodispersions containing spherical particles with sizes ranging from 66.20-125.25 nm, depending on the type of surfactant used. SDS and SDS-Tween 80 surfactants negatively affected the viability of the HT-29 cells used in this study. Thus, for the cellular uptake determination, only Tween 80 and sodium caseinate surfactants were used. The cellular uptake of the lutein nanodispersion stabilized by sodium caseinate was higher than that which was stabilized by Tween 80. All things considered, the type of surfactant with different stabilizing mechanisms did produce lutein nanodispersions with different characteristics. These findings would aid in future selection of surfactants in order to produce nanodispersions with desirable properties.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 21%
Professor > Associate Professor 3 16%
Professor 2 11%
Lecturer > Senior Lecturer 2 11%
Researcher 2 11%
Other 4 21%
Unknown 2 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 16%
Chemical Engineering 2 11%
Engineering 2 11%
Biochemistry, Genetics and Molecular Biology 2 11%
Medicine and Dentistry 1 5%
Other 4 21%
Unknown 5 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#5,595,102
of 7,396,084 outputs
Outputs from Food & Function
#695
of 1,255 outputs
Outputs of similar age
#194,156
of 275,550 outputs
Outputs of similar age from Food & Function
#48
of 118 outputs
Altmetric has tracked 7,396,084 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,255 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,550 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.