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Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB

Overview of attention for article published in Journal of Neuroinflammation, February 2012
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Title
Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB
Published in
Journal of Neuroinflammation, February 2012
DOI 10.1186/1742-2094-9-39
Pubmed ID
Authors

Sen Lin, Yajie Liang, Jiqiang Zhang, Chen Bian, Hongli Zhou, Qiang Guo, Ying Xiong, Shurong Li, Bingyin Su

Abstract

TIR-domain-containing adapter-inducing interferon-β (TRIF) is the sole downstream adaptor of Toll-like receptor (TLR)3, which is one of the major signaling pathways in immune cells leading to neuroinflammation in the central nervous system. Overexpression of TRIF may lead to activation of inflammatory responses, and contribute to pathophysiological progression in both acute and chronic neurodegenerative retinal diseases. In the present study, was aimed to elucidate the contributions of TRIF to optic nerve (ON) regeneration and retinal ganglion cell (RGC) survival following injury to the ON, a widely studied model of central nervous system injury and of degenerative diseases such as glaucoma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Student > Ph. D. Student 5 17%
Researcher 5 17%
Student > Bachelor 4 13%
Professor > Associate Professor 4 13%
Other 4 13%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 37%
Medicine and Dentistry 7 23%
Neuroscience 5 17%
Unspecified 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 1 3%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2012.
All research outputs
#3,108,250
of 4,505,992 outputs
Outputs from Journal of Neuroinflammation
#468
of 659 outputs
Outputs of similar age
#49,207
of 79,048 outputs
Outputs of similar age from Journal of Neuroinflammation
#18
of 29 outputs
Altmetric has tracked 4,505,992 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 659 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 79,048 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.