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Mendeley readers
| Chapter title |
Determining Competitive Potential of Bone Metastatic Cancer Cells in the Murine Hematopoietic Stem Cell Niche
|
|---|---|
| Chapter number | 178 |
| Book title |
Stem Cell Niche
|
| Published in |
Methods in molecular biology, August 2018
|
| DOI | 10.1007/7651_2018_178 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-9507-3, 978-1-4939-9508-0
|
| Authors |
Sun H. Park, Matthew R. Eber, Russell S. Taichman, Yusuke Shiozawa |
| Abstract |
The ability of cancer cells to compete with hematopoietic stem cells (HSCs) to target the bone marrow microenvironment, or the HSC niche, during the dissemination process is critical for the development of bone metastasis. Here, we describe the methods for testing the relative potential of cancer cells to compete with HSCs for occupancy of the HSC niche by measuring the peripheral blood level of engrafted HSCs by flow cytometry in mice after bone marrow transplantation and tandem cancer cell inoculation. This method is useful for determining the molecular mechanisms for the roles of HSCs in the regulation of bone metastases. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 33% |
| Student > Ph. D. Student | 1 | 17% |
| Student > Master | 1 | 17% |
| Unknown | 2 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 33% |
| Agricultural and Biological Sciences | 1 | 17% |
| Engineering | 1 | 17% |
| Unknown | 2 | 33% |