You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples
|
|---|---|
| Published in |
PLOS ONE, March 2016
|
| DOI | 10.1371/journal.pone.0151240 |
| Pubmed ID | |
| Authors |
Llinos G. Harris, Susan Murray, Ben Pascoe, James Bray, Guillaume Meric, Leonardos Magerios, Thomas S. Wilkinson, Rose Jeeves, Holger Rohde, Stefan Schwarz, Herminia de Lencastre, Maria Miragaia, Joana Rolo, Rory Bowden, Keith A. Jolley, Martin C. J. Maiden, Dietrich Mack, Samuel K. Sheppard |
| Abstract |
Bacterial species comprise related genotypes that can display divergent phenotypes with important clinical implications. Staphylococcus epidermidis is a common cause of nosocomial infections and, critical to its pathogenesis, is its ability to adhere and form biofilms on surfaces, thereby moderating the effect of the host's immune response and antibiotics. Commensal S. epidermidis populations are thought to differ from those associated with disease in factors involved in adhesion and biofilm accumulation. We quantified the differences in biofilm formation in 98 S. epidermidis isolates from various sources, and investigated population structure based on ribosomal multilocus typing (rMLST) and the presence/absence of genes involved in adhesion and biofilm formation. All isolates were able to adhere and form biofilms in in vitro growth assays and confocal microscopy allowed classification into 5 biofilm morphotypes based on their thickness, biovolume and roughness. Phylogenetic reconstruction grouped isolates into three separate clades, with the isolates in the main disease associated clade displaying diversity in morphotype. Of the biofilm morphology characteristics, only biofilm thickness had a significant association with clade distribution. The distribution of some known adhesion-associated genes (aap and sesE) among isolates showed a significant association with the species clonal frame. These data challenge the assumption that biofilm-associated genes, such as those on the ica operon, are genetic markers for less invasive S. epidermidis isolates, and suggest that phenotypic characteristics, such as adhesion and biofilm formation, are not fixed by clonal descent but are influenced by the presence of various genes that are mobile among lineages. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| United Kingdom | 1 | 33% |
| Portugal | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 103 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 21% |
| Student > Master | 14 | 13% |
| Student > Bachelor | 14 | 13% |
| Student > Ph. D. Student | 10 | 10% |
| Professor | 6 | 6% |
| Other | 16 | 15% |
| Unknown | 23 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 23% |
| Agricultural and Biological Sciences | 16 | 15% |
| Immunology and Microbiology | 14 | 13% |
| Medicine and Dentistry | 14 | 13% |
| Engineering | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 23 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2016.
All research outputs
#14,254,293
of 22,856,968 outputs
Outputs from PLOS ONE
#116,772
of 194,934 outputs
Outputs of similar age
#158,693
of 299,392 outputs
Outputs of similar age from PLOS ONE
#3,053
of 5,328 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,934 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,392 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,328 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.