Title |
Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye?
|
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Published in |
Journal of Autism and Developmental Disorders, January 2011
|
DOI | 10.1007/s10803-010-1171-z |
Pubmed ID | |
Authors |
Asimenia Angelidou, Konstantinos-Dionysios Alysandratos, Shahrzad Asadi, Bodi Zhang, Konstantinos Francis, Magdalini Vasiadi, Dimitrios Kalogeromitros, Theoharis C. Theoharides |
Abstract |
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of "allergic symptomatology", often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
Unknown | 6 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 3% |
Netherlands | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 92 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 18% |
Student > Bachelor | 15 | 15% |
Student > Master | 13 | 13% |
Other | 8 | 8% |
Student > Ph. D. Student | 8 | 8% |
Other | 18 | 19% |
Unknown | 18 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 27% |
Psychology | 12 | 12% |
Agricultural and Biological Sciences | 11 | 11% |
Social Sciences | 7 | 7% |
Neuroscience | 5 | 5% |
Other | 17 | 18% |
Unknown | 19 | 20% |