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Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, March 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
7 tweeters

Citations

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32 Dimensions

Readers on

mendeley
66 Mendeley
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Title
Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
Published in
Memórias do Instituto Oswaldo Cruz, March 2016
DOI 10.1590/0074-02760150401
Pubmed ID
Authors

Marisa Liliana Fernández, Maria Elena Marson, Juan Carlos Ramirez, Guido Mastrantonio, Alejandro Gabriel Schijman, Jaime Altcheh, Adelina Rosa Riarte, Facundo García Bournissen

Abstract

Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABARAX®) in doses between 2.5-5.5 mg/Kg/day. All but one patient had plasmatic BNZ concentrations within the expected range. All patients finalised treatment with nondetectable Trypanosoma cruzi quantitative polymerase chain reaction, which remained nondetectable at the six month follow-up. Our data suggests parasitological responses with the new BNZ and supports the hypothesis that treatment protocols with lower BNZ doses may be effective.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
Colombia 1 2%
Unknown 63 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 18%
Researcher 9 14%
Student > Doctoral Student 7 11%
Student > Ph. D. Student 7 11%
Other 5 8%
Other 11 17%
Unknown 15 23%
Readers by discipline Count As %
Medicine and Dentistry 11 17%
Agricultural and Biological Sciences 10 15%
Biochemistry, Genetics and Molecular Biology 7 11%
Chemistry 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Other 7 11%
Unknown 20 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2016.
All research outputs
#4,283,474
of 16,011,650 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#147
of 1,140 outputs
Outputs of similar age
#75,594
of 267,407 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#2
of 14 outputs
Altmetric has tracked 16,011,650 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,140 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,407 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.