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In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides

Overview of attention for article published in Journal of Applied Oral Science, January 2016
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  • High Attention Score compared to outputs of the same age and source (86th percentile)

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Title
In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides
Published in
Journal of Applied Oral Science, January 2016
DOI 10.1590/1678-775720150352
Pubmed ID
Authors

Patrick Schmidlin, Katja Zobrist, Thomas Attin, Florian Wegehaupt

Abstract

Objectives To assess the re-hardening potential of enamel matrix derivatives (EMD) and self-assembling peptides in vitro, hypothesizing that these materials may increase the mineralization of artificial carious lesions and improve hardness profiles. Material and Methods Forty-eight enamel samples were prepared from extracted bovine lower central incisors. After embedding and polishing, nail varnish was applied, leaving a defined test area. One third of this area was covered with a flowable composite (non-demineralized control). The remaining area was demineralized in an acidic buffer solution for 18 d to simulate a carious lesion. Half the demineralized area was then covered with composite (demineralized control), while the last third was left open for three test and one control treatments: (A) Application of enamel-matrix proteins (EMD - lyophilized protein fractions dissolved in acetic acid, Straumann), (B) self-assembling peptides (SAP, Curodont), or (C) amine fluoride solution (Am-F, GABA) for 5 min each. Untreated samples (D) served as control. After treatment, samples were immersed in artificial saliva for four weeks (remineralization phase) and microhardness (Knoop) depth profiles (25-300 µm) were obtained at sections. Two-way ANOVA was calculated to determine differences between the areas (re-hardening or softening). Results Decalcification resulted in significant softening of the subsurface enamel in all groups (A-D). A significant re-hardening up to 125 µm was observed in the EMD and SAP groups. Conclusions This study showed that EMD and SAP were able to improve the hardness profiles when applied to deep demineralized artificial lesions. However, further research is needed to verify and improve this observed effect.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 117 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 15%
Student > Master 16 14%
Student > Postgraduate 11 9%
Researcher 6 5%
Student > Doctoral Student 5 4%
Other 15 13%
Unknown 47 40%
Readers by discipline Count As %
Medicine and Dentistry 47 40%
Unspecified 4 3%
Engineering 3 3%
Energy 2 2%
Agricultural and Biological Sciences 2 2%
Other 12 10%
Unknown 47 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2022.
All research outputs
#8,261,140
of 25,371,288 outputs
Outputs from Journal of Applied Oral Science
#91
of 596 outputs
Outputs of similar age
#122,046
of 399,675 outputs
Outputs of similar age from Journal of Applied Oral Science
#3
of 30 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 596 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,675 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.