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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
|
|---|---|
| Published in |
Nature Communications, March 2016
|
| DOI | 10.1038/ncomms10944 |
| Pubmed ID | |
| Authors |
Shuhei Nakamura, Özlem Karalay, Philipp S. Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E. Templer, Christoph Dieterich, Adam Antebi |
| Abstract |
Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised of Mondo/Max-like complex (MML-1/MXL-2) to be required for longevity induced by germline removal, as well as by reduced TOR, insulin/IGF signalling and mitochondrial function. Germline removal increases MML-1 nuclear accumulation and activity. Surprisingly, MML-1 regulates nuclear localization and activity of HLH-30/TFEB, a convergent regulator of autophagy, lysosome biogenesis and longevity, by downregulating TOR signalling via LARS-1/leucyl-transfer RNA synthase. HLH-30 also upregulates MML-1 upon germline removal. Mammalian MondoA/B and TFEB show similar mutual regulation. MML-1/MXL-2 and HLH-30 transcriptomes show both shared and preferential outputs including MDL-1/MAD-like HLH factor required for longevity. These studies reveal how an extensive interdependent HLH transcription factor network distributes responsibility and mutually enforces states geared towards reproduction or survival. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 18% |
| Mexico | 1 | 9% |
| Spain | 1 | 9% |
| Unknown | 7 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 91% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 126 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 20% |
| Researcher | 20 | 16% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 11 | 9% |
| Professor > Associate Professor | 8 | 6% |
| Other | 21 | 17% |
| Unknown | 29 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 46 | 36% |
| Agricultural and Biological Sciences | 27 | 21% |
| Medicine and Dentistry | 9 | 7% |
| Physics and Astronomy | 4 | 3% |
| Immunology and Microbiology | 2 | 2% |
| Other | 9 | 7% |
| Unknown | 30 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2017.
All research outputs
#835,331
of 23,567,572 outputs
Outputs from Nature Communications
#13,868
of 49,108 outputs
Outputs of similar age
#15,715
of 301,700 outputs
Outputs of similar age from Nature Communications
#240
of 799 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,108 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,700 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 799 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.