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Non-invasive and label-free detection of oral squamous cell carcinoma using saliva surface-enhanced Raman spectroscopy and multivariate analysis

Overview of attention for article published in Nanomedicine: Nanotechnology, Biology and Medicine, August 2016
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Mentioned by

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2 tweeters

Citations

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15 Dimensions

Readers on

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50 Mendeley
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Title
Non-invasive and label-free detection of oral squamous cell carcinoma using saliva surface-enhanced Raman spectroscopy and multivariate analysis
Published in
Nanomedicine: Nanotechnology, Biology and Medicine, August 2016
DOI 10.1016/j.nano.2016.02.021
Pubmed ID
Authors

Jennifer M. Connolly, Karen Davies, Agne Kazakeviciute, Antony M. Wheatley, Peter Dockery, Ivan Keogh, Malini Olivo

Abstract

Reported here is the application of silver nanoparticle-based surface-enhanced Raman spectroscopy (SERS) as a label-free, non-invasive technique for detection of oral squamous cell cancer (OSCC) using saliva and desquamated oral cells. A total of 180 SERS spectra were acquired from saliva and 120 SERS spectra from oral cells collected from normal healthy individuals and from confirmed oropharyngeal cancer patients. Notable biochemical peaks in the SERS spectra were tentatively assigned to various components. Data were subjected to multivariate statistical techniques including principal component analysis and linear discriminate analysis (PCA-LDA) revealing a sensitivity of 89% and 68% and a diagnostic accuracy of 73% and 60% for saliva and oral cells, respectively. The results from this study demonstrate the potential of saliva and oral cell SERS combined with PCA-LDA diagnostic algorithms as a promising clinical adjunct for the non-invasive detection of oral cancer.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 2%
United Kingdom 1 2%
Unknown 48 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 18%
Researcher 7 14%
Student > Ph. D. Student 7 14%
Student > Master 7 14%
Student > Doctoral Student 3 6%
Other 8 16%
Unknown 9 18%
Readers by discipline Count As %
Engineering 6 12%
Medicine and Dentistry 6 12%
Chemistry 6 12%
Biochemistry, Genetics and Molecular Biology 5 10%
Materials Science 3 6%
Other 9 18%
Unknown 15 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2018.
All research outputs
#10,325,601
of 13,528,132 outputs
Outputs from Nanomedicine: Nanotechnology, Biology and Medicine
#627
of 1,088 outputs
Outputs of similar age
#169,512
of 264,308 outputs
Outputs of similar age from Nanomedicine: Nanotechnology, Biology and Medicine
#20
of 53 outputs
Altmetric has tracked 13,528,132 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,088 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,308 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.