Title |
Role of dendritic cells in the induction of regulatory T cells
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Published in |
Cell & Bioscience, May 2011
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DOI | 10.1186/2045-3701-1-20 |
Pubmed ID | |
Authors |
Rahul Kushwah, Jim Hu |
Abstract |
Dendritic cells (DCs) play a key role in initiating immune responses and maintaining immune tolerance. In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which are dependent on IL-10, TGF-β, retinoic acid, indoleamine-2,3,-dioxygenase along with vitamin D. Several of these mechanisms are employed by DCs in induction of regulatory T cells which are comprised of Tr1 regulatory T cells, natural and inducible foxp3+ regulatory T cells, Th3 regulatory T cells and double negative regulatory T cells. It appears that certain DC subsets are highly specialized in inducing regulatory T cell differentiation and in some tissues the local microenvironment plays a role in driving DCs towards a tolerogenic response. In this review we discuss the recent advances in our understanding of the mechanisms underlying DC driven regulatory T cell induction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | <1% |
Turkey | 1 | <1% |
Indonesia | 1 | <1% |
Ireland | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Other | 1 | <1% |
Unknown | 205 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 57 | 27% |
Student > Bachelor | 33 | 15% |
Student > Master | 30 | 14% |
Researcher | 25 | 12% |
Student > Doctoral Student | 9 | 4% |
Other | 29 | 13% |
Unknown | 32 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 84 | 39% |
Immunology and Microbiology | 32 | 15% |
Medicine and Dentistry | 31 | 14% |
Biochemistry, Genetics and Molecular Biology | 13 | 6% |
Nursing and Health Professions | 2 | <1% |
Other | 11 | 5% |
Unknown | 42 | 20% |