Infectivity. “While in others [prion diseases] transmissible PrP amyloids may variably co-propagate with authentic prions and act as a major modifier of clinicopathological phenotype.” (PrP = misfolded host-encoded prion protein). https://t.co/qQzBWohp6H
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Infectivity. “In some inherited prion diseases transmissible PrP amyloids only may be generated.” (PrP = misfolded host-encoded prion protein). https://t.co/qQzBWohp6H
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Isoform subset. “The prototypical PrPSc and indeed prions per se may not themselves be highly neurotoxic.” (PrPSc = the conformationally altered prion isoform). https://t.co/qQzBWohp6H
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Isoform subset. “It is now thought that a distinct oligomeric or monomeric PrP isoform designated PrPL (for lethal) may comprise the neurotoxic species.” (PrP = misfolded host-encoded prion protein; PrPC = The Cellular Prion Protein). https://t.co/qQzBWoh