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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis
|
|---|---|
| Published in |
BMC Infectious Diseases, March 2016
|
| DOI | 10.1186/s12879-016-1468-4 |
| Pubmed ID | |
| Authors |
M. M. G. Leeflang, C. W. Ang, J. Berkhout, H. A. Bijlmer, W. Van Bortel, A. H. Brandenburg, N. D. Van Burgel, A. P. Van Dam, R. B. Dessau, V. Fingerle, J. W. R. Hovius, B. Jaulhac, B. Meijer, W. Van Pelt, J. F. P. Schellekens, R. Spijker, F. F. Stelma, G. Stanek, F. Verduyn-Lunel, H. Zeller, H. Sprong |
| Abstract |
Interpretation of serological assays in Lyme borreliosis requires an understanding of the clinical indications and the limitations of the currently available tests. We therefore systematically reviewed the accuracy of serological tests for the diagnosis of Lyme borreliosis in Europe. We searched EMBASE en MEDLINE and contacted experts. Studies evaluating the diagnostic accuracy of serological assays for Lyme borreliosis in Europe were eligible. Study selection and data-extraction were done by two authors independently. We assessed study quality using the QUADAS-2 checklist. We used a hierarchical summary ROC meta-regression method for the meta-analyses. Potential sources of heterogeneity were test-type, commercial or in-house, Ig-type, antigen type and study quality. These were added as covariates to the model, to assess their effect on test accuracy. Seventy-eight studies evaluating an Enzyme-Linked ImmunoSorbent assay (ELISA) or an immunoblot assay against a reference standard of clinical criteria were included. None of the studies had low risk of bias for all QUADAS-2 domains. Sensitivity was highly heterogeneous, with summary estimates: erythema migrans 50 % (95 % CI 40 % to 61 %); neuroborreliosis 77 % (95 % CI 67 % to 85 %); acrodermatitis chronica atrophicans 97 % (95 % CI 94 % to 99 %); unspecified Lyme borreliosis 73 % (95 % CI 53 % to 87 %). Specificity was around 95 % in studies with healthy controls, but around 80 % in cross-sectional studies. Two-tiered algorithms or antibody indices did not outperform single test approaches. The observed heterogeneity and risk of bias complicate the extrapolation of our results to clinical practice. The usefulness of the serological tests for Lyme disease depends on the pre-test probability and subsequent predictive values in the setting where the tests are being used. Future diagnostic accuracy studies should be prospectively planned cross-sectional studies, done in settings where the test will be used in practice. |
X Demographics
The data shown below were collected from the profiles of 52 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 21% |
| United Kingdom | 9 | 17% |
| Canada | 3 | 6% |
| France | 2 | 4% |
| Finland | 2 | 4% |
| Netherlands | 2 | 4% |
| Germany | 1 | 2% |
| Unknown | 22 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 38 | 73% |
| Practitioners (doctors, other healthcare professionals) | 7 | 13% |
| Science communicators (journalists, bloggers, editors) | 5 | 10% |
| Scientists | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 2 | 1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 180 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 16% |
| Student > Bachelor | 25 | 13% |
| Student > Master | 21 | 11% |
| Other | 18 | 10% |
| Student > Ph. D. Student | 15 | 8% |
| Other | 41 | 22% |
| Unknown | 37 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 33% |
| Agricultural and Biological Sciences | 18 | 10% |
| Immunology and Microbiology | 13 | 7% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Nursing and Health Professions | 6 | 3% |
| Other | 30 | 16% |
| Unknown | 46 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2021.
All research outputs
#673,401
of 25,332,933 outputs
Outputs from BMC Infectious Diseases
#157
of 8,542 outputs
Outputs of similar age
#12,001
of 307,341 outputs
Outputs of similar age from BMC Infectious Diseases
#3
of 93 outputs
Altmetric has tracked 25,332,933 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,341 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.