Title |
The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures
|
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Published in |
Nature Communications, March 2016
|
DOI | 10.1038/ncomms11098 |
Pubmed ID | |
Authors |
Elliot H. Smith, Jyun-you Liou, Tyler S. Davis, Edward M. Merricks, Spencer S. Kellis, Shennan A. Weiss, Bradley Greger, Paul A. House, Guy M. McKhann II, Robert R. Goodman, Ronald G. Emerson, Lisa M. Bateman, Andrew J. Trevelyan, Catherine A. Schevon |
Abstract |
The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale. We hypothesize that seizures evolve into self-organized structures wherein a small seizing territory projects high-intensity electrical signals over a broad cortical area. Here we investigate human seizures on both small and large electrophysiological scales. We show that the migrating edge of the seizing territory is the source of travelling waves of synaptic activity into adjacent cortical areas. As the seizure progresses, slow dynamics in induced activity from these waves indicate a weakening and eventual failure of their source. These observations support a parsimonious theory for how large-scale evolution and termination of seizures are driven from a small, migrating cortical area. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 29% |
United Kingdom | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 203 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 46 | 22% |
Researcher | 41 | 20% |
Student > Master | 16 | 8% |
Student > Doctoral Student | 15 | 7% |
Student > Bachelor | 14 | 7% |
Other | 33 | 16% |
Unknown | 41 | 20% |
Readers by discipline | Count | As % |
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Neuroscience | 52 | 25% |
Engineering | 27 | 13% |
Medicine and Dentistry | 25 | 12% |
Agricultural and Biological Sciences | 21 | 10% |
Physics and Astronomy | 5 | 2% |
Other | 20 | 10% |
Unknown | 56 | 27% |