Title |
Emerging applications of riboswitches – from antibacterial targets to molecular tools
|
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Published in |
Journal of Applied Genetics, March 2016
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DOI | 10.1007/s13353-016-0341-x |
Pubmed ID | |
Authors |
Piotr Machtel, Kamilla Bąkowska-Żywicka, Marek Żywicki |
Abstract |
The ability to precisely regulate gene expression is one of the most important features of the living cells as it enables the adaptation and survival in different environmental conditions. The majority of regulatory mechanisms involve protein action, however, multiple genes are controlled by nucleic acids. Among RNA-based regulators, the riboswitches present a large group of specific domains within messenger RNAs able to respond to small metabolites, tRNA, secondary messengers, ions, vitamins or amino acids. A simple, accurate, and efficient mechanism of action as well as easiness in handling and engineering make the riboswitches a potent practical tool in industry, medicine, pharmacy or environmental protection. Hereby, we summarize the current achievements and challenges in designing and practical employment of the riboswitch-based tools. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
China | 1 | <1% |
Unknown | 177 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 44 | 25% |
Student > Master | 34 | 19% |
Student > Bachelor | 26 | 15% |
Researcher | 21 | 12% |
Student > Doctoral Student | 8 | 4% |
Other | 11 | 6% |
Unknown | 35 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 77 | 43% |
Agricultural and Biological Sciences | 24 | 13% |
Chemistry | 17 | 9% |
Immunology and Microbiology | 8 | 4% |
Chemical Engineering | 3 | 2% |
Other | 11 | 6% |
Unknown | 39 | 22% |