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Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis

Overview of attention for article published in PLOS ONE, February 2012
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Title
Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis
Published in
PLOS ONE, February 2012
DOI 10.1371/journal.pone.0032479
Pubmed ID
Authors

Aditya K. Padhi, Hirdesh Kumar, Suhas V. Vasaikar, Bhyravabhotla Jayaram, James Gomes

Abstract

Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics (MD) simulations of wild-type ANG and disease associated ANG variants to elucidate the mechanism behind the loss of ribonucleolytic activity and nuclear translocation activity, functions needed for angiogenesis.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 3%
Korea, Republic of 1 2%
India 1 2%
Canada 1 2%
Unknown 59 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 23%
Student > Bachelor 11 17%
Student > Master 8 13%
Student > Doctoral Student 6 9%
Researcher 6 9%
Other 12 19%
Unknown 6 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 31%
Biochemistry, Genetics and Molecular Biology 11 17%
Medicine and Dentistry 9 14%
Neuroscience 5 8%
Chemistry 4 6%
Other 8 13%
Unknown 7 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2012.
All research outputs
#15,242,707
of 22,663,969 outputs
Outputs from PLOS ONE
#129,810
of 193,506 outputs
Outputs of similar age
#99,554
of 155,414 outputs
Outputs of similar age from PLOS ONE
#2,116
of 3,499 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,506 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,414 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,499 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.