Title |
Clinical correlates of grey matter pathology in multiple sclerosis
|
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Published in |
BMC Neurology, March 2012
|
DOI | 10.1186/1471-2377-12-10 |
Pubmed ID | |
Authors |
Dana Horakova, Tomas Kalincik, Jana Blahova Dusankova, Ondrej Dolezal |
Abstract |
Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histological changes as well as of molecular targets within the grey matter has arisen. This advance was driven mainly by novel imaging techniques, however, these have not yet been implemented in routine clinical practice. The changes in the grey matter are related to physical and cognitive disability seen in individuals with multiple sclerosis. Furthermore, damage to several grey matter structures can be associated with impairment of specific functions. Therefore, we conclude that grey matter damage - global and regional - has the potential to become a marker of disease activity, complementary to the currently used magnetic resonance markers (global brain atrophy and T2 hyperintense lesions). Furthermore, it may improve the prediction of the future disease course and response to therapy in individual patients and may also become a reliable additional surrogate marker of treatment effect. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 17% |
Spain | 1 | 17% |
Argentina | 1 | 17% |
United States | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
Italy | 2 | 1% |
Spain | 2 | 1% |
South Africa | 1 | <1% |
Brazil | 1 | <1% |
Russia | 1 | <1% |
Czechia | 1 | <1% |
Unknown | 139 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 17% |
Student > Master | 25 | 17% |
Researcher | 22 | 15% |
Student > Doctoral Student | 15 | 10% |
Other | 14 | 9% |
Other | 36 | 24% |
Unknown | 11 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 60 | 40% |
Neuroscience | 26 | 17% |
Psychology | 22 | 15% |
Agricultural and Biological Sciences | 12 | 8% |
Nursing and Health Professions | 2 | 1% |
Other | 7 | 5% |
Unknown | 20 | 13% |