Title |
Common Variants in the TPH2 Promoter Confer Susceptibility to Paranoid Schizophrenia
|
---|---|
Published in |
Journal of Molecular Neuroscience, March 2012
|
DOI | 10.1007/s12031-012-9725-5 |
Pubmed ID | |
Authors |
Zhenghui Yi, Chen Zhang, Weihong Lu, Lisheng Song, Dentang Liu, Yifeng Xu, Yiru Fang |
Abstract |
Serotonergic system-related genes may be good candidates in investigating the genetic basis of schizophrenia. Our previous study suggested that promoter region of tryptophan hydroxylase 2 gene (TPH2) may confer the susceptibility to paranoid schizophrenia. In this study, we investigated whether common variants within TPH2 promoter may predispose to paranoid schizophrenia in Han Chinese. A total of 509 patients who met DSM-IV criteria for paranoid schizophrenia and 510 matched healthy controls were recruited for this study. Five polymorphisms within TPH2 promoter region were tested. No statistically significant differences were found in allele or genotype frequencies between schizophrenic patients and healthy controls. The frequency of the rs4448731T-rs6582071A-rs7963803A-rs4570625T-rs11178997A haplotype was significantly higher in cases compared to the controls (P = 0.003; OR = 1.49; 95% CI, 1.15-1.95). Our results suggest that the common variants within TPH2 promoter are associated with paranoid schizophrenia in Han Chinese. Further studies in larger samples are warranted to elucidate the role of TPH2 in the etiology of paranoid schizophrenia. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 12% |
Unknown | 15 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 24% |
Student > Ph. D. Student | 3 | 18% |
Researcher | 3 | 18% |
Student > Bachelor | 2 | 12% |
Professor > Associate Professor | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 24% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Medicine and Dentistry | 2 | 12% |
Nursing and Health Professions | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Other | 3 | 18% |
Unknown | 4 | 24% |