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Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer

Overview of attention for article published in Science, March 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
12 news outlets
blogs
3 blogs
twitter
23 tweeters
patent
1 patent

Citations

dimensions_citation
73 Dimensions

Readers on

mendeley
126 Mendeley
citeulike
1 CiteULike
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Title
Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer
Published in
Science, March 2016
DOI 10.1126/science.aad8352
Pubmed ID
Authors

Matteo De Poli, Wojciech Zawodny, Ophélie Quinonero, Mark Lorch, Simon J. Webb, Jonathan Clayden

Abstract

The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution. Here we report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biological membrane phase. These molecules contain a chromophore, which can be switched between two configurations by different wavelengths of light, attached to a helical oligoamide that both promotes membrane insertion and communicates conformational change along its length. Light-induced structural changes in the chromophore are translated into global conformational changes, detected by monitoring the solid state(19)F nuclear magnetic resonance signals of a remote fluorine-containing residue located 1 to 2 nm away. The behavior of the foldamers in the membrane phase is similar to that of analogous compounds in organic solvents.

Twitter Demographics

The data shown below were collected from the profiles of 23 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Netherlands 1 <1%
United Kingdom 1 <1%
Czechia 1 <1%
Unknown 121 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 31%
Researcher 23 18%
Student > Master 18 14%
Student > Bachelor 10 8%
Professor 7 6%
Other 19 15%
Unknown 10 8%
Readers by discipline Count As %
Chemistry 80 63%
Biochemistry, Genetics and Molecular Biology 7 6%
Agricultural and Biological Sciences 7 6%
Chemical Engineering 4 3%
Physics and Astronomy 3 2%
Other 12 10%
Unknown 13 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 124. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2020.
All research outputs
#180,862
of 16,652,557 outputs
Outputs from Science
#6,267
of 69,425 outputs
Outputs of similar age
#4,946
of 267,455 outputs
Outputs of similar age from Science
#170
of 1,092 outputs
Altmetric has tracked 16,652,557 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 69,425 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 53.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,455 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,092 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.