Report for: N-Acetylaspartate

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Chapter title	Canavan Disease: Studies on the Knockout Mouse
Chapter number	6
Book title	N-Acetylaspartate
Published in	Advances in experimental medicine and biology, June 2006
DOI	10.1007/0-387-30172-0_6
Pubmed ID	16802706
Book ISBNs	978-0-387-30171-6, 978-0-387-30172-3
Authors	Matalon R, Michals-Matalon K, Surendran S, Tyring SK, Reuben Matalon, Kimberlee Michals-Matalon, Sankar Surendran, Stephen K. Tyring
Abstract	Canavan disease (CD) is an autosomal recessive disorder, characterized by spongy degeneration of the brain. Patients with CD have aspartoacylase (ASPA) deficiency, which results accumulation of N-acetylaspartic acid (NAA) in the brain and elevated excretion of urinary NAA. Clinically, patients with CD have macrocephaly, mental retardation and hypotonia. A knockout mouse for CD which was engineered, also has ASPA deficiency and elevated NAA. Molecular studies of the mouse brain showed abnormal expression of multiple genes in addition to ASPA deficiency. Adenoassociated virus mediated gene transfer and stem cell therapy in the knockout mouse are the latest attempts to alter pathophysiology in the CD mouse.

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Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	15	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	5	33%
Student > Bachelor	4	27%
Other	2	13%
Student > Postgraduate	1	7%
Unknown	3	20%

Readers by discipline	Count	As %
Medicine and Dentistry	7	47%
Agricultural and Biological Sciences	3	20%
Biochemistry, Genetics and Molecular Biology	2	13%
Computer Science	1	7%
Neuroscience	1	7%
Other	0	0%
Unknown	1	7%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2018.

All research outputs

#7,451,284

of 22,780,165 outputs

Outputs from Advances in experimental medicine and biology

#1,226

of 4,930 outputs

Outputs of similar age

#22,573

of 64,153 outputs

Outputs of similar age from Advances in experimental medicine and biology

of 2 outputs

Altmetric has tracked 22,780,165 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.

So far Altmetric has tracked 4,930 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 65% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 64,153 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.

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N-Acetylaspartate

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Geographical breakdown

Demographic breakdown

Attention Score in Context