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N-Acetylaspartate

Overview of attention for book
Cover of 'N-Acetylaspartate'

Table of Contents

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    Book Overview
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    Chapter 1 A Brief Overview of N -Acetylaspartate and N -Acetylaspartylglutamate
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    Chapter 2 Expression of N -Acetylaspartate and N -Acetylaspartylglutamate in the Nervous System
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    Chapter 3 N -Acetylaspartate Metabolism in Neural Cells
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    Chapter 4 Naa Synthesis and Functional Roles
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    Chapter 5 Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the N -Acetyl-L-Aspartate Transporter
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    Chapter 6 Canavan Disease: Studies on the Knockout Mouse
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    Chapter 7 Functions Of N -Acetylaspartate and N -Acetylaspartylglutamate in Brain
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    Chapter 8 Control of Brain Volume during Hypoosmolality and Hyperosmolality
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    Chapter 9 Physiological Role of N -Acetylaspartate
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    Chapter 10 Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canavan Disease
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    Chapter 11 Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease
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    Chapter 12 Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?
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    Chapter 13 Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy
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    Chapter 14 N-Acetyl-L-Aspartate in Multiple Sclerosis
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    Chapter 15 NAA and higher cognitive function in humans.
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    Chapter 16 In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia
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    Chapter 17 N -Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease
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    Chapter 18 Regulation of NAA-Synthesis in the Human Brain in Vivo: Canavan’s Disease, Alzheimer’s Disease and Schizophrenia
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    Chapter 19 Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis
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    Chapter 20 Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient
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    Chapter 21 Cellular localization of NAAG.
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    Chapter 22 Synthesis of N-acetylaspartyl-glutamate (NAAG) and N-acetylaspartate (NAA) in axons and glia of the crayfish medial giant nerve fiber.
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    Chapter 23 NAAG as a neurotransmitter.
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    Chapter 24 Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.
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    Chapter 25 N-acetylaspartylglutamate (NAAG) in spinal cord injury and disease.
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    Chapter 26 N-acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher disease.
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    Chapter 27 Concluding Remarks
Attention for Chapter 6: Canavan Disease: Studies on the Knockout Mouse
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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2 Wikipedia pages

Citations

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27 Dimensions

Readers on

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15 Mendeley
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Chapter title
Canavan Disease: Studies on the Knockout Mouse
Chapter number 6
Book title
N-Acetylaspartate
Published in
Advances in experimental medicine and biology, June 2006
DOI 10.1007/0-387-30172-0_6
Pubmed ID
Book ISBNs
978-0-387-30171-6, 978-0-387-30172-3
Authors

Matalon R, Michals-Matalon K, Surendran S, Tyring SK, Reuben Matalon, Kimberlee Michals-Matalon, Sankar Surendran, Stephen K. Tyring

Abstract

Canavan disease (CD) is an autosomal recessive disorder, characterized by spongy degeneration of the brain. Patients with CD have aspartoacylase (ASPA) deficiency, which results accumulation of N-acetylaspartic acid (NAA) in the brain and elevated excretion of urinary NAA. Clinically, patients with CD have macrocephaly, mental retardation and hypotonia. A knockout mouse for CD which was engineered, also has ASPA deficiency and elevated NAA. Molecular studies of the mouse brain showed abnormal expression of multiple genes in addition to ASPA deficiency. Adenoassociated virus mediated gene transfer and stem cell therapy in the knockout mouse are the latest attempts to alter pathophysiology in the CD mouse.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 33%
Student > Bachelor 5 33%
Student > Postgraduate 2 13%
Other 1 7%
Unknown 2 13%
Readers by discipline Count As %
Medicine and Dentistry 7 47%
Agricultural and Biological Sciences 2 13%
Biochemistry, Genetics and Molecular Biology 2 13%
Computer Science 1 7%
Neuroscience 1 7%
Other 1 7%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2018.
All research outputs
#3,641,928
of 12,532,910 outputs
Outputs from Advances in experimental medicine and biology
#581
of 3,195 outputs
Outputs of similar age
#78,550
of 274,139 outputs
Outputs of similar age from Advances in experimental medicine and biology
#46
of 270 outputs
Altmetric has tracked 12,532,910 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,195 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,139 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 270 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.