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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
|
|---|---|
| Published in |
Nature Communications, April 2016
|
| DOI | 10.1038/ncomms11138 |
| Pubmed ID | |
| Authors |
Muhammad M. Mohiuddin, Avneesh K. Singh, Philip C. Corcoran, Marvin L. Thomas III, Tannia Clark, Billeta G. Lewis, Robert F. Hoyt, Michael Eckhaus, Richard N. Pierson III, Aaron J. Belli, Eckhard Wolf, Nikolai Klymiuk, Carol Phelps, Keith A. Reimann, David Ayares, Keith A. Horvath |
| Abstract |
Preventing xenograft rejection is one of the greatest challenges of transplantation medicine. Here, we describe a reproducible, long-term survival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express human complement regulatory protein CD46 and human thrombomodulin (GTKO.hCD46.hTBM), that were transplanted into baboons. Our immunomodulatory drug regimen includes induction with anti-thymocyte globulin and αCD20 antibody, followed by maintenance with mycophenolate mofetil and an intensively dosed αCD40 (2C10R4) antibody. Median (298 days) and longest (945 days) graft survival in five consecutive recipients using this regimen is significantly prolonged over our recently established survival benchmarks (180 and 500 days, respectively). Remarkably, the reduction of αCD40 antibody dose on day 100 or after 1 year resulted in recrudescence of anti-pig antibody and graft failure. In conclusion, genetic modifications (GTKO.hCD46.hTBM) combined with the treatment regimen tested here consistently prevent humoral rejection and systemic coagulation pathway dysregulation, sustaining long-term cardiac xenograft survival beyond 900 days. |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 15% |
| Spain | 4 | 7% |
| Japan | 2 | 4% |
| Philippines | 1 | 2% |
| India | 1 | 2% |
| United Kingdom | 1 | 2% |
| Sweden | 1 | 2% |
| Finland | 1 | 2% |
| France | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 35 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 42 | 76% |
| Scientists | 7 | 13% |
| Science communicators (journalists, bloggers, editors) | 4 | 7% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Sweden | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 157 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 17% |
| Researcher | 20 | 12% |
| Student > Ph. D. Student | 16 | 10% |
| Student > Master | 16 | 10% |
| Other | 11 | 7% |
| Other | 22 | 13% |
| Unknown | 51 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 16% |
| Agricultural and Biological Sciences | 26 | 16% |
| Biochemistry, Genetics and Molecular Biology | 23 | 14% |
| Immunology and Microbiology | 6 | 4% |
| Veterinary Science and Veterinary Medicine | 5 | 3% |
| Other | 19 | 12% |
| Unknown | 58 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1030. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2023.
All research outputs
#15,511
of 25,559,053 outputs
Outputs from Nature Communications
#300
of 57,618 outputs
Outputs of similar age
#229
of 315,932 outputs
Outputs of similar age from Nature Communications
#6
of 818 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,618 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,932 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 818 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.