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Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells

Overview of attention for article published in International Journal of Nanomedicine, April 2016
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

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3 tweeters

Citations

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29 Dimensions

Readers on

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67 Mendeley
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Title
Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells
Published in
International Journal of Nanomedicine, April 2016
DOI 10.2147/ijn.s95850
Pubmed ID
Authors

Han, Dae Hwan Shin, Jung Seok Kim, Kwon Yeon Weon, Chang-Young Jang, Jin-Seok Kim

Abstract

Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs) is important because these cells are regarded as culprit of breast cancer relapse. Accomplishing this kind of strategy requires a specific drug-delivery system using the distinct features of liposomes. Studies on targeted liposomal delivery systems have indicated the conjugation of hyaluronan (HA), a primary ligand for CD44 surface markers, as an appropriate method for targeting BCSCs. For this study, enriched BCSCs were obtained by culturing MCF-7 breast cancer cells in nonadherent conditions. The enriched BCSCs were challenged with HA-conjugated liposomes encapsulating gemcitabine (2, 2-difluoro-2-deoxycytidine, GEM). In vitro study showed that the HA-conjugated liposomes significantly enhanced the cytotoxicity, anti-migration, and anti-colony formation abilities of GEM through targeting of CD44 expressed on BCSCs. In pharmacokinetic study, area under the drug concentration vs time curve (AUC) of the immunoliposomal GEM was 3.5 times higher than that of free GEM, indicating that the HA-conjugated liposomes enhanced the stability of GEM in the bloodstream and therefore prolonged its half-life time. The antitumor effect of the immunoliposomal GEM was 3.3 times higher than that of free GEM in a xenograft mouse model, probably reflecting the unique targeting of the CD44 receptor by HA and the increased cytotoxicity and stability through the liposomal formulation. Furthermore, marginal change in body weight demonstrated that the use of liposomes considerably reduced the systemic toxicity of GEM on normal healthy cells. Taken together, this study demonstrates that HA-conjugated liposomes encapsulating GEM show promise for the therapy of breast cancer in vitro and in a xenograft model by targeting the BCSCs.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 18%
Researcher 11 16%
Student > Ph. D. Student 11 16%
Student > Master 11 16%
Student > Doctoral Student 3 4%
Other 11 16%
Unknown 8 12%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 17 25%
Medicine and Dentistry 11 16%
Biochemistry, Genetics and Molecular Biology 10 15%
Agricultural and Biological Sciences 7 10%
Chemistry 4 6%
Other 5 7%
Unknown 13 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2016.
All research outputs
#3,437,742
of 7,523,579 outputs
Outputs from International Journal of Nanomedicine
#516
of 1,706 outputs
Outputs of similar age
#124,131
of 271,241 outputs
Outputs of similar age from International Journal of Nanomedicine
#43
of 110 outputs
Altmetric has tracked 7,523,579 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 1,706 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.