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Frequency of Cardiovascular Involvement in Familial Amyloidotic Polyneuropathy in Brazilian Patients

Overview of attention for article published in Arquivos Brasileiros de Cardiologia, January 2015
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Title
Frequency of Cardiovascular Involvement in Familial Amyloidotic Polyneuropathy in Brazilian Patients
Published in
Arquivos Brasileiros de Cardiologia, January 2015
DOI 10.5935/abc.20150112
Pubmed ID
Authors

Márcia Cavalcanti de Campos Queiroz, Roberto Coury Pedrosa, Amanda Cardoso Berensztejn, Basílio de Bragança Pereira, Emília Matos do Nascimento, Martha Maria Turano Duarte, Pedro Paulo Pereira-Junior, Marcia Waddington Cruz

Abstract

Familial amyloidotic polyneuropathy (FAP) is a rare disease diagnosed in Brazil and worldwide. The frequency of cardiovascular involvement in Brazilian FAP patients is unknown. Detect the frequency of cardiovascular involvement and correlate the cardiovascular findings with the modified polyneuropathy disability (PND) score. In a national reference center, 51 patients were evaluated with clinical examination, electrocardiography (ECG), echocardiography (ECHO), and 24-hour Holter. Patients were classified according to the modified PND score and divided into groups: PND 0, PND I, PND II, and PND > II (which included PND IIIa, IIIb, and IV). We chose the classification tree as the statistical method to analyze the association between findings in cardiac tests with the neurological classification (PND). ECG abnormalities were present in almost 2/3 of the FAP patients, whereas ECHO abnormalities occurred in around 1/3 of them. All patients with abnormal ECHO also had abnormal ECG, but the opposite did not apply. The classification tree identified ECG and ECHO as relevant variables (p < 0.001 and p = 0.08, respectively). The probability of a patient to be allocated to the PND 0 group when having a normal ECG was over 80%. When both ECG and ECHO were abnormal, this probability was null. Brazilian patients with FAP have frequent ECG abnormalities. ECG is an appropriate test to discriminate asymptomatic carriers of the mutation from those who develop the disease, whereas ECHO contributes to this discrimination.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 21%
Student > Bachelor 4 14%
Student > Ph. D. Student 4 14%
Researcher 3 11%
Professor > Associate Professor 2 7%
Other 4 14%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 9 32%
Biochemistry, Genetics and Molecular Biology 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Agricultural and Biological Sciences 2 7%
Nursing and Health Professions 1 4%
Other 4 14%
Unknown 7 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2016.
All research outputs
#10,420,713
of 13,643,660 outputs
Outputs from Arquivos Brasileiros de Cardiologia
#311
of 513 outputs
Outputs of similar age
#168,329
of 261,703 outputs
Outputs of similar age from Arquivos Brasileiros de Cardiologia
#1
of 1 outputs
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