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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Selection of Target Sites for Mobile DNA Integration in the Human Genome
|
|---|---|
| Published in |
PLoS Computational Biology, November 2006
|
| DOI | 10.1371/journal.pcbi.0020157 |
| Pubmed ID | |
| Authors |
Charles Berry, Sridhar Hannenhalli, Jeremy Leipzig, Frederic D Bushman |
| Abstract |
DNA sequences from retroviruses, retrotransposons, DNA transposons, and parvoviruses can all become integrated into the human genome. Accumulation of such sequences accounts for at least 40% of our genome today. These integrating elements are also of interest as gene-delivery vectors for human gene therapy. Here we present a comprehensive bioinformatic analysis of integration targeting by HIV, MLV, ASLV, SFV, L1, SB, and AAV. We used a mathematical method which allowed annotation of each base pair in the human genome for its likelihood of hosting an integration event by each type of element, taking advantage of more than 200 types of genomic annotation. This bioinformatic resource documents a wealth of new associations between genomic features and integration targeting. The study also revealed that the length of genomic intervals analyzed strongly affected the conclusions drawn--thus, answering the question "What genomic features affect integration?" requires carefully specifying the length scale of interest. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 11% |
| Australia | 2 | 6% |
| Comoros | 1 | 3% |
| Unknown | 29 | 81% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 83% |
| Scientists | 6 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Finland | 2 | 1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Unknown | 146 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 25% |
| Student > Ph. D. Student | 34 | 22% |
| Student > Master | 16 | 10% |
| Professor > Associate Professor | 12 | 8% |
| Student > Bachelor | 7 | 4% |
| Other | 21 | 13% |
| Unknown | 27 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 38% |
| Biochemistry, Genetics and Molecular Biology | 31 | 20% |
| Computer Science | 11 | 7% |
| Medicine and Dentistry | 9 | 6% |
| Immunology and Microbiology | 9 | 6% |
| Other | 10 | 6% |
| Unknown | 28 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2023.
All research outputs
#1,902,688
of 25,888,065 outputs
Outputs from PLoS Computational Biology
#1,639
of 9,065 outputs
Outputs of similar age
#5,488
of 169,709 outputs
Outputs of similar age from PLoS Computational Biology
#4
of 24 outputs
Altmetric has tracked 25,888,065 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,065 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.