Title |
Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?
|
---|---|
Published in |
Critical Care, March 2012
|
DOI | 10.1186/cc11256 |
Pubmed ID | |
Authors |
Demet Demirkol, Dincer Yildizdas, Benan Bayrakci, Bulent Karapinar, Tanil Kendirli, Tolga F Koroglu, Oguz Dursun, Nilgün Erkek, Hakan Gedik, Agop Citak, Selman Kesici, Metin Karabocuoglu, Joseph A Carcillo, Turkish Secondary HLH/MAS Critical Care Study Group |
Abstract |
Hyperferritinemia is associated with increased mortality in pediatric sepsis, multiple organ dysfunction syndrome (MODS), and critical illness. The International Histiocyte Society has recommended that children with hyperferritinemia and secondary hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) should be treated with the same immunosuppressant/cytotoxic therapies used to treat primary HLH. We hypothesized that patients with hyperferritinemia associated secondary HLH/sepsis/MODS/MAS can be successfully treated with a less immunosuppressant approach than is recommended for primary HLH. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Belgium | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 124 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 17% |
Other | 21 | 16% |
Student > Master | 15 | 12% |
Student > Postgraduate | 13 | 10% |
Student > Doctoral Student | 8 | 6% |
Other | 23 | 18% |
Unknown | 26 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 79 | 62% |
Agricultural and Biological Sciences | 4 | 3% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Nursing and Health Professions | 2 | 2% |
Business, Management and Accounting | 2 | 2% |
Other | 11 | 9% |
Unknown | 28 | 22% |