Title |
A comparison of two distinct murine macrophage gene expression profiles in response to Leishmania amazonensisinfection
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Published in |
BMC Microbiology, February 2012
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DOI | 10.1186/1471-2180-12-22 |
Pubmed ID | |
Authors |
Christian M Probst, Rodrigo A Silva, Juliana P B Menezes, Tais F Almeida, Ivana N Gomes, Andréia C Dallabona, Luiz S Ozaki, Gregory A Buck, Daniela P Pavoni, Marco A Krieger, Patrícia S T Veras |
Abstract |
The experimental murine model of leishmaniasis has been widely used to characterize the immune response against Leishmania. CBA mice develop severe lesions, while C57BL/6 present small chronic lesions under L. amazonensis infection. Employing a transcriptomic approach combined with biological network analysis, the gene expression profiles of C57BL/6 and CBA macrophages, before and after L. amazonensis infection in vitro, were compared. These strains were selected due to their different degrees of susceptibility to this parasite. |
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