Title |
Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
|
---|---|
Published in |
BMC Cancer, March 2012
|
DOI | 10.1186/1471-2407-12-109 |
Pubmed ID | |
Authors |
Michael Heise, Anja Lautem, Johanna Knapstein, Jörn M Schattenberg, Maria Hoppe-Lotichius, Daniel Foltys, Nina Weiler, Anca Zimmermann, Arno Schad, Dirk Gründemann, Gerd Otto, Peter R Galle, Marcus Schuchmann, Tim Zimmermann |
Abstract |
Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transporters became pharmaceutically interesting, because OCTs are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. No data exist about the relevance of OCTs in hepatocellular carcinoma (HCC). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
France | 1 | 2% |
Germany | 1 | 2% |
Unknown | 47 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 36% |
Student > Ph. D. Student | 8 | 16% |
Student > Master | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Professor > Associate Professor | 3 | 6% |
Other | 8 | 16% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 26% |
Biochemistry, Genetics and Molecular Biology | 9 | 18% |
Agricultural and Biological Sciences | 7 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 14% |
Chemistry | 2 | 4% |
Other | 5 | 10% |
Unknown | 7 | 14% |