Title |
Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review
|
---|---|
Published in |
PLOS ONE, March 2012
|
DOI | 10.1371/journal.pone.0033275 |
Pubmed ID | |
Authors |
Sophia B. Georghiou, Marisa Magana, Richard S. Garfein, Donald G. Catanzaro, Antonino Catanzaro, Timothy C. Rodwell |
Abstract |
Rapid molecular diagnostics for detecting multidrug-resistant and extensively drug-resistant tuberculosis (M/XDR-TB) primarily identify mutations in Mycobacterium tuberculosis (Mtb) genes associated with drug resistance. Their accuracy, however, is dependent largely on the strength of the association between a specific mutation and the phenotypic resistance of the isolate with that mutation, which is not always 100%. While this relationship is well established and reliable for first-line anti-TB drugs, rifampin and isoniazid, it is less well-studied and understood for second-line, injectable drugs, amikacin (AMK), kanamycin (KAN) and capreomycin (CAP). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 3 | 1% |
Portugal | 1 | <1% |
India | 1 | <1% |
Russia | 1 | <1% |
United States | 1 | <1% |
Unknown | 292 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 59 | 20% |
Researcher | 46 | 15% |
Student > Ph. D. Student | 46 | 15% |
Student > Bachelor | 28 | 9% |
Other | 17 | 6% |
Other | 49 | 16% |
Unknown | 54 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 67 | 22% |
Biochemistry, Genetics and Molecular Biology | 52 | 17% |
Medicine and Dentistry | 50 | 17% |
Immunology and Microbiology | 27 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 3% |
Other | 31 | 10% |
Unknown | 63 | 21% |