You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Improved Cellular Specificity of Plasmonic Nanobubbles versus Nanoparticles in Heterogeneous Cell Systems
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0034537 |
| Pubmed ID | |
| Authors |
Ekaterina Y. Lukianova-Hleb, Xiaoyang Ren, Pamela E. Constantinou, Brian P. Danysh, Derek L. Shenefelt, Daniel D. Carson, Mary C. Farach-Carson, Vladimir A. Kulchitsky, Xiangwei Wu, Daniel S. Wagner, Dmitri O. Lapotko |
| Abstract |
The limited specificity of nanoparticle (NP) uptake by target cells associated with a disease is one of the principal challenges of nanomedicine. Using the threshold mechanism of plasmonic nanobubble (PNB) generation and enhanced accumulation and clustering of gold nanoparticles in target cells, we increased the specificity of PNB generation and detection in target versus non-target cells by more than one order of magnitude compared to the specificity of NP uptake by the same cells. This improved cellular specificity of PNBs was demonstrated in six different cell models representing diverse molecular targets such as epidermal growth factor receptor, CD3 receptor, prostate specific membrane antigen and mucin molecule MUC1. Thus PNBs may be a universal method and nano-agent that overcome the problem of non-specific uptake of NPs by non-target cells and improve the specificity of NP-based diagnostics, therapeutics and theranostics at the cell level. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 56 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 31% |
| Researcher | 11 | 19% |
| Student > Master | 6 | 10% |
| Professor > Associate Professor | 4 | 7% |
| Professor | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Physics and Astronomy | 9 | 16% |
| Chemistry | 9 | 16% |
| Agricultural and Biological Sciences | 7 | 12% |
| Engineering | 7 | 12% |
| Materials Science | 5 | 9% |
| Other | 11 | 19% |
| Unknown | 10 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2017.
All research outputs
#817,997
of 22,664,267 outputs
Outputs from PLOS ONE
#11,312
of 193,506 outputs
Outputs of similar age
#4,196
of 161,135 outputs
Outputs of similar age from PLOS ONE
#170
of 3,716 outputs
Altmetric has tracked 22,664,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,506 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,135 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 3,716 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.