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Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam

Overview of attention for article published in Brazilian Journal of Anesthesiology (English edition), May 2016
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Title
Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam
Published in
Brazilian Journal of Anesthesiology (English edition), May 2016
DOI 10.1016/j.bjane.2014.09.014
Pubmed ID
Authors

Jose Francisco Nunes Pereira das Neves, Mariana Moraes Pereira das Neves Araújo, Fernando de Paiva Araújo, Clarice Martins Ferreira, Fabiana Baeta Neves Duarte, Fabio Heleno Pace, Laura Cotta Ornellas, Todd H. Baron

Abstract

Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated when undergoing examination, although the best combination of drugs has not been determined. The combination of opioids and benzodiazepines is used to relieve the patient's pain and discomfort. More recently, propofol has assumed a prominent position. This randomized prospective study is unique in medical literature that specifically compared the use of propofol and fentanyl with or without midazolam for colonoscopy sedation performed by anesthesiologists. The aim of this study was to evaluate the side effects of sedation, discharge conditions, quality of sedation, and propofol consumption during colonoscopy, with or without midazolam as preanesthetic. The study involved 140 patients who underwent colonoscopy at the University Hospital of the Federal University of Juiz de Fora. Patients were divided into two groups: Group I received intravenous midazolam as preanesthetic 5min before sedation, followed by fentanyl and propofol; Group II received intravenous anesthesia with fentanyl and propofol. Patients in Group II had a higher incidence of reaction (motor or verbal) to the colonoscope introduction, bradycardia, hypotension, and increased propofol consumption. Patient satisfaction was higher in Group I. According to the methodology used, the combination of midazolam, fentanyl, and propofol for colonoscopy sedation reduces propofol consumption and provides greater patient satisfaction.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 16%
Researcher 7 12%
Student > Postgraduate 5 9%
Student > Master 5 9%
Other 4 7%
Other 8 14%
Unknown 19 33%
Readers by discipline Count As %
Medicine and Dentistry 17 30%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Agricultural and Biological Sciences 4 7%
Nursing and Health Professions 3 5%
Business, Management and Accounting 2 4%
Other 6 11%
Unknown 20 35%