RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
RT @imatomirainoms: コロンビアのある集落で、アルツハイマー病遺伝子を持ちながら、認知症の進行が見られない女性が発見されたと報告がありました。 APOEというタンパクの遺伝子に珍しい変異があり、それが病気の進行を阻止している模様。 未だ混沌を極めるアルツハイマ…
RT @NatureMedicine: Or significant advances in the development of new therapies in humans, such as this Ph1 trial testing the safety of mac…
RT @NatureMedicine: Or significant advances in the development of new therapies in humans, such as this Ph1 trial testing the safety of mac…
Or significant advances in the development of new therapies in humans, such as this Ph1 trial testing the safety of macrophage therapy for liver cirrhosis > https://t.co/4A5Vci9GhF or this case report of a patient resistant to development of #Alzheimers
RT @AFALU_alzheimer: La variante genética del #alzheimer afecta a un 5% de los casos, en la revista Nature se publica un caso en el que ad…
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report | Nature Medicine https://t.co/VdoDcV6JPE
RT @ytquiroz: So excited to share our latest work on #familial #Alzheimers!😊 A report published @NatureMedicine describes an individual who…
RT @AndreaBackman05: This is a remarkable finding, one that gives us hope for protection against those who carry a genetic predisposition t…
RT @SchreiberStuart: Cautionary note for N = 1 claims such as the single Christchurch apoE3 variant causing protection of a "monogenic" ear…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @MarcelloIenca: Report of a PSEN1 mutation carrier from world’s largest autosomal dominant Alzheimer’s disease kindred who did not devel…
RT @xulong82: MGH also set up fundraising to support the awesome authors! @ytquiroz Here: https://t.co/GdAIMq1AvB https://t.co/C5d4cAXfyr
MGH also set up fundraising to support the awesome authors! @ytquiroz Here: https://t.co/GdAIMq1AvB
Two groundbreaking work highlighting the critical role of APOE on AD. Here: https://t.co/ZFaBlcVKkA And here: https://t.co/Ct2YGAy8jX Great work for all the AD patients waiting for a treatment!
RT @JesusAnturi: Aporte a #ElDesparche de hoy sobre esa enfermedad que acaba con la memoria: un artículo de Intellecta @Uninorte https://t.…
RT @davidaguillon3: @UdeA @medicina_udea @DLarraneta @ElDesparche_ @elcolombiano El seguimiento de estas familias permitió descubrir una mu…
RT @JesusAnturi: Aporte a #ElDesparche de hoy sobre esa enfermedad que acaba con la memoria: un artículo de Intellecta @Uninorte https://t.…
RT @JesusAnturi: Aporte a #ElDesparche de hoy sobre esa enfermedad que acaba con la memoria: un artículo de Intellecta @Uninorte https://t.…
Report of a PSEN1 mutation carrier from world’s largest autosomal dominant Alzheimer’s disease kindred who did not develop mild cognitive impairment until her 70s, 30y after the expected age of clinical onset. Big implications for the role of APOE in AD. h
RT @JesusAnturi: Aporte a #ElDesparche de hoy sobre esa enfermedad que acaba con la memoria: un artículo de Intellecta @Uninorte https://t.…
RT @davidaguillon3: @UdeA @medicina_udea @DLarraneta @ElDesparche_ @elcolombiano El seguimiento de estas familias permitió descubrir una mu…
RT @davidaguillon3: @UdeA @medicina_udea @DLarraneta @ElDesparche_ @elcolombiano El seguimiento de estas familias permitió descubrir una mu…
RT @davidaguillon3: @UdeA @medicina_udea @DLarraneta @ElDesparche_ @elcolombiano El seguimiento de estas familias permitió descubrir una mu…
Aporte a #ElDesparche de hoy sobre esa enfermedad que acaba con la memoria: un artículo de Intellecta @Uninorte https://t.co/y5nvtJYdx6 con la investigación en genética de la población antioqueña que la padece. @mezuba
@UdeA @medicina_udea @DLarraneta @ElDesparche_ @elcolombiano El seguimiento de estas familias permitió descubrir una mujer con un caso nunca antes registrado, con un gen protector que retrasó el inicio de la enfermedad de Alzheimer por 30 años https://t.co
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @ANordenMD: I hesitate to make too much of a single case....but this could have major implications for #Alzheimers therapy. https://t.c…
RT @SchreiberStuart: Cautionary note for N = 1 claims such as the single Christchurch apoE3 variant causing protection of a "monogenic" ear…
RT @SchreiberStuart: Cautionary note for N = 1 claims such as the single Christchurch apoE3 variant causing protection of a "monogenic" ear…
RT @SchreiberStuart: Cautionary note for N = 1 claims such as the single Christchurch apoE3 variant causing protection of a "monogenic" ear…
RT @SchreiberStuart: Cautionary note for N = 1 claims such as the single Christchurch apoE3 variant causing protection of a "monogenic" ear…
Cautionary note for N = 1 claims such as the single Christchurch apoE3 variant causing protection of a "monogenic" early onset AD PSEN1 allele: polygenic risk powerfully modifies the risk conferred by monogenic risk variants. Time to reassess https://t.co/
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
Very important to explore disease modifying mutations for any diseases. Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report | Nature Medicine https://t.co/uiFVkZ6qbo
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @BiotechMania: せめて今月Nature Medicine誌に掲載されたAPOEのホモ変異によりアミロイド蓄積が異常タウタンパク質蓄積や神経変性、認知機能低下と分離されている事例を踏まえて、内容や図表を作成していただきたいです。 https://t.co/3S…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
せめて今月Nature Medicine誌に掲載されたAPOEのホモ変異によりアミロイド蓄積が異常タウタンパク質蓄積や神経変性、認知機能低下と分離されている事例を踏まえて、内容や図表を作成していただきたいです。 https://t.co/3SyagwEQIA https://t.co/A2wuw8Kus6
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
Resistance to autosomal dominant Alzheimer disease in an APOE3 Christchurch homozygote: a case report <https://t.co/1IcnB6Tmhn> #Alzheimer R & D requires new approaches based on > 200 drug trials have failed in human trails/ animal models to h
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @ytquiroz: wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL jour…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
wow! 20,000 article accesses in only 3 weeks! 😳 In the 99th %ile of the 246,949 tracked articles of a similar age in ALL journals, and in the 98th %ile of the tracked articles of a similar age in @NatureMedicine! 👍🏼 So exciting!#ResistAlz #COLBOS @MGHmapp
#Alzheimer #brain Does APOE3 protect against Alzheimer's? APOE variants have previously been linked to AD. A new study identified a woman with APOE3ch, who was partially protected against an early onset form of AD! But careful, it is a still a case report.
RT @ytquiroz: What an exciting week! 😊Thanks for reading and sharing our @NatureMedicine case report!👍🏼 Some article metrics so far: 12K ar…
RT @imatomirainoms: コロンビアのある集落で、アルツハイマー病遺伝子を持ちながら、認知症の進行が見られない女性が発見されたと報告がありました。 APOEというタンパクの遺伝子に珍しい変異があり、それが病気の進行を阻止している模様。 未だ混沌を極めるアルツハイマ…
RT @ytquiroz: What an exciting week! 😊Thanks for reading and sharing our @NatureMedicine case report!👍🏼 Some article metrics so far: 12K ar…
Resistance to AD Alzheimer’s disease in an APOE3 Christchurch homozygote https://t.co/nYUVwCBYWS
Tau again! Also check out another finding showing the importance of tau over amyloid... https://t.co/6fvDRUc3bb
RT @AndyBiotech: Why are some people resistant to #Alzheimer’s? https://t.co/HaPtnlxNFo Fascinating story on AD genetics! Homozygous APOE3…
RT @F1000Prime: The path of most resistance: a case report recommended by Fowzan Alkuraya @KFSHRC_Research shows that a patient with #Alzhe…
The path of most resistance: a case report recommended by Fowzan Alkuraya @KFSHRC_Research shows that a patient with #Alzheimer’s and two copies of the APOE3 Christchurch mutation showed an unexpected resistance to mild #cognitive #impairments https://t.co
It’s been a couple weeks since this paper came out but it keeps me thinking about the genetic variation in humans that can help us learn about risk factor biology. The search for protective factors may be as important as the search for risk factors.
RT @AfghaniHani: #سبحان_الله_العظيم سمعتم بطفرةجينية🧬مفيدة🤔... في سابقةولأول مرة تم اكتشاف طفرة🧬جينية نادرةفي جينAPOEفي👵مصابةبطفرة في جينPS…
RT @ytquiroz: What an exciting week! 😊Thanks for reading and sharing our @NatureMedicine case report!👍🏼 Some article metrics so far: 12K ar…
RT @BioDecoded: Why Didn’t She Get Alzheimer’s? The Answer Could Hold a Key to Fighting the Disease | The New York Times https://t.co/iJ7fs…
A mutation that may be protective from #Alzheimers https://t.co/FwKm8blioU @lior_golomb @NatureMedicine https://t.co/zVjCWbbWxi
Autosomal dominant Alzheimer’s disease mitigated by APOE3 Christchurch homozygosis https://t.co/UkKCUtEPN8 #Alzheimers Individual had a PSEN1 mutation as part of a large kindred of early AD However, they did not develop AD symptoms until their 70s rathe
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
RT @AfghaniHani: #سبحان_الله_العظيم سمعتم بطفرةجينية🧬مفيدة🤔... في سابقةولأول مرة تم اكتشاف طفرة🧬جينية نادرةفي جينAPOEفي👵مصابةبطفرة في جينPS…
RT @NeuroTransmitOz: Great paper in Nature medicine! Study describes a clinical case of someone harboring a rare #APOE mutation that confer…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
I hesitate to make too much of a single case....but this could have major implications for #Alzheimers therapy. https://t.co/T3ZseM5iGm
Capaz la evolución encontró la inmunidad ante el Alzheimar, tras generaciones y generación en la misma rama genealógica. https://t.co/lcVWpmlpmj
Great paper in Nature medicine! Study describes a clinical case of someone harboring a rare #APOE mutation that confers resistance to inherited #Alzheimer's disease, despite elevated brain #amyloid https://t.co/Th2MKUdWuV @NatureMedicine @alzassociation h
RT @AfghaniHani: #سبحان_الله_العظيم سمعتم بطفرةجينية🧬مفيدة🤔... في سابقةولأول مرة تم اكتشاف طفرة🧬جينية نادرةفي جينAPOEفي👵مصابةبطفرة في جينPS…
RT @biome393: 2019 Arboleda-Velasquez, Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case rep…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
RT @biome393: 2019 Arboleda-Velasquez, Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case rep…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
2019 Arboleda-Velasquez, Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report, https://t.co/1nWVdppZYf #alzheimers #brainhealth #BrainFunction
RT @BioDecoded: Why Didn’t She Get Alzheimer’s? The Answer Could Hold a Key to Fighting the Disease | The New York Times https://t.co/iJ7fs…
This case study shows the case of a 70-year old, #healthy woman who was supposed to develop #AlzheimersDisease in her 50s. Why she didn't develop #Alzheimers? A mutation in the #APOE gene! https://t.co/gKlhE6NoYT #science #healthscience #researchpaper
RT @AfghaniHani: #سبحان_الله_العظيم سمعتم بطفرةجينية🧬مفيدة🤔... في سابقةولأول مرة تم اكتشاف طفرة🧬جينية نادرةفي جينAPOEفي👵مصابةبطفرة في جينPS…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
RT @BioDecoded: Why Didn’t She Get Alzheimer’s? The Answer Could Hold a Key to Fighting the Disease | The New York Times https://t.co/iJ7fs…
RT @AfghaniHani: #سبحان_الله_العظيم سمعتم بطفرةجينية🧬مفيدة🤔... في سابقةولأول مرة تم اكتشاف طفرة🧬جينية نادرةفي جينAPOEفي👵مصابةبطفرة في جينPS…
RT @BioDecoded: Why Didn’t She Get Alzheimer’s? The Answer Could Hold a Key to Fighting the Disease | The New York Times https://t.co/iJ7fs…
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
Alzheimer's Disease is more complex than the beta-amyloid theory postulated. Hello, Evidence-based Medicine guys! It is a case report stronger than several meta-analyses using non-harmonized observational studies.
RT @NatureMedicine: Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytqui…
This is profound, despite brain full of amyloid, a rare mutation in #ApoE led to relative resistance to #Alzheimers
Why Didn’t She Get Alzheimer’s? The Answer Could Hold a Key to Fighting the Disease | The New York Times https://t.co/iJ7fs5c3hw https://t.co/hjFprTaRGV #Alzheimers https://t.co/hSKr8WKK1q
RT @brunovellas: Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report | Nature Medicine…
RT @chinmayharidas: The E280A mutation causes early onset Alzheimer’s disease (AD) by the late 40s. Fantastic work by @ytquiroz #ResistAlz…
In this new report on #Alzheimer #Dementia resistance in a PS1 mutation patient a case can be made that the APOE binding properties to neuronal heparan sulfate mediate to a large extend the susceptibility fopr the disease. #Glycobiology matters. https://t.